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Solid-State Nanopore Sensors: State-of-the-Art and Perspectives

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Nanosensors".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 55

Special Issue Editor

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Guest Editor
Department of Physics, University of Arkansas, 226 Physics Building, 825 West Dickson Street, Fayetteville, AR 72701, USA
Interests: solid-state nanopore fabrication; micro- and nanostructure; single-molecule DNA sequencing; single-molecule protein analysis; polymer physics; single-biomolecule manipulation and detection; fluid walls
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Special Issue Information

Dear Colleagues,

This Special Issue aims to include a collection of recent developments in solid-state nanopore technique sensing biomolecules. Inspired and motivated by making synthetic ion channels like protein channels in cell membranes, solid-state nanopores of adjustable sizes and geometries have been fabricated since 2000 in insulating membranes such as silicon nitride and silicon dioxide. Solid-state nanopore-based sensing devices have been developed and used for analyzing single molecules of DNA, RNA, proteins of native and unfolded states, protein–protein interactions, protein–DNA complexes, and the interactions of these molecules with other analytes. The advantages of the solid-state nanopore technique include the following: (1) the measurement of biomolecules can be performed under solution conditions very close to the native state, while varying temperature, pH, and salt concentration at the single molecule level; (2) the nanopore technique is fast, ~10 minutes to measure about 5000 molecules with a small sample (~10 mL of 100 nM or ~10 pM); (3) the nanopores can be fabricated with the size and geometry required for the biomolecules to be detected. To be able to characterize the properties such as their electrical charge, shape, volume, dipole moment, and Brownian motion under these solution conditions, one molecule at a time at high speed will be important and valuable, which can improve our understanding of how these molecules function and interact, advance the development of nanobiotechnology, and allow new approaches to solve problems in biological and medical sciences.

Dr. Jiali Li
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • nanopore sensors
  • DNA and RNA nanopore analysis
  • protein nanopore analysis

Published Papers

This special issue is now open for submission.
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