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The Kidneys in Autoimmune Disease: From Basic Mechanisms to Clinical...
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The Kidneys in Autoimmune Disease: From Basic Mechanisms to Clinical Outcomes

A special issue of Rheumato (ISSN 2674-0621).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3177

Special Issue Editors

Dr. Peter Korsten

E-Mail Website
Guest Editor
Section Head of Rheumatology, Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany
Interests: systemic lupus erythematosus; lupus nephritis; sarcoidosis; systemic sclerosis; interstitial lung disease; myositis; vasculitis; emergency medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Björn Tampe

E-Mail Website
Guest Editor
Section Head of Critical Care Medicine, Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany
Interests: kidney injury; kidney fibrosis; ANCA-associated vasculitis; inflammation; Covid-19; cytokine storm; hyper inflammation; Intensive Care Medicine; dialysis; vascular access

Special Issue Information

Dear Colleagues,

The kidneys are major organs affected by systemic autoimmune diseases, and acute kidney injury in these conditions has increased mortality. With this Special Issue, we aim to give an overview of systemic autoimmune diseases with a preference for kidney involvement. These include systemic vasculitis, systemic lupus erythematosus, and underrecognized conditions, such as primary Sjögren’s syndrome or sarcoidosis. In the latter condition, affection of the kidneys is rare, but newer studies show a higher prevalence of renal sarcoidosis than previously reported.

The recognition of renal manifestations in these conditions is crucial to improve the overall survival of patients. However, with the advent of novel therapeutic agents for many of these conditions, it is still unclear how they fit in the current therapeutic approaches considering costs, risks, benefits, and availability. Nevertheless, these are exciting times for clinicians facing complex systemic diseases with severe and often refractory organ manifestations.

This Special Issue aims to provide a broad overview of current and new knowledge on renal manifestations in systemic autoimmune diseases, including original studies and reviews on histopathology, biomarkers, clinical outcomes, and novel therapeutic strategies, especially using immunomodulating therapies.

Dr. Peter Korsten
Dr. Björn Tampe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Rheumato is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • systemic lupus erythematosus
  • lupus nephritis belimumab
  • ANCA-associated vasculitis
  • glomerulonephritis
  • acute kidney injury
  • histopathology
  • sarcoidosis

Published Papers (1 paper)

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Research

12 pages, 1553 KiB  
Article
A Preliminary Predictive Model for Proliferative Lupus Nephritis in Juvenile Systemic Lupus Erythematosus
by Sern Chin Lim, Elaine Wan Ling Chan, Shikriti Suprakash Mandal and Swee Ping Tang
Rheumato 2023, 3(1), 86-97; https://doi.org/10.3390/rheumato3010007 - 22 Feb 2023
Viewed by 1719
Abstract
Proliferative lupus nephritis, which is diagnosed by renal biopsy, has significant impact on the treatment choices and long-term prognosis of juvenile SLE (jSLE). Renal biopsies are however not always possible or available, thus leading to an ongoing search for alternative biomarkers. This study [...] Read more.
Proliferative lupus nephritis, which is diagnosed by renal biopsy, has significant impact on the treatment choices and long-term prognosis of juvenile SLE (jSLE). Renal biopsies are however not always possible or available, thus leading to an ongoing search for alternative biomarkers. This study aimed to develop a clinical predictive machine learning model using routine standard parameters as an alternative tool to evaluate the probability of proliferative lupus nephritis (ISN/RPS Class III or IV). Data were collected retrospectively from jSLE patients seen at Selayang Hospital from 2004 to 2021. A total of 22 variables including demographic, clinical and laboratory features were analyzed. A recursive feature elimination technique was used to identify factors to predict pediatric proliferative lupus nephritis. Various models were then used to build predictive machine learning models and assessed for sensitivity, specificity and accuracy. There were 194 jSLE patients (165 females), of which 111 had lupus nephritis (54 proliferative pattern). A combination of 11 variables consisting of gender, ethnicity, fever, nephrotic state, hypertension, urine red blood cells (RBC), C3, C4, duration of illness, serum albumin, and proteinuria demonstrated the highest accuracy of 79.4% in predicting proliferative lupus nephritis. A decision-tree model performed the best with an AROC of 69.9%, accuracy of 73.85%, sensitivity of 78.72% and specificity of 61.11%. A potential clinically useful predictive model using a combination of 11 non-invasive variables to collectively predict pediatric proliferative lupus nephritis in daily practice was developed. Full article
(This article belongs to the Special Issue The Kidneys in Autoimmune Disease: From Basic Mechanisms to Clinical Outcomes)
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