Radiation Biology

A special issue of Radiation (ISSN 2673-592X).

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 2209

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Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapei Rd., Niaosong Dist., Kaohsiung City 833, Taiwan
Interests: radiotherapy in brain tumor; liver tumor; breast cancer; lymphoma; stereotactic brain radiosurgery; SRS; stereotactic body radiation therapy; SBRT
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Special Issue Information

Dear Colleagues,

Radiation biology is a multidisciplinary field that examines the biological effects of radiation on cells, tissues, and organisms. By integrating elements of biology, physics, chemistry, and medicine, radiobiology explores how ionizing radiation interacts with living matter at the cellular and molecular levels. Among the fundamental concepts of radiobiology lies the impairment of DNA by ionizing radiation, encompassing mechanisms of DNA repair and dose–response relationships. However, beyond these known aspects, there remain intriguing and unrevealed changes within the microenvironment following ionizing radiation exposure. Understanding the intricate ways in which radiation influences the cellular and tissue surroundings, impacting both healthy and cancerous cells, becomes crucial in the development of effective cancer treatment strategies.

We cordially invite you to contribute to this esteemed Special Issue. This edition aims to explore the diverse scope of research related to the effects of radiation on biological targets. The topics covered include, but are not limited to:

  1. The impact of radiation on environmental health.
  2. Radiobiology in the context of space exploration.
  3. Radiation safety and protection measures.
  4. Advancements in medical radiation therapy.
  5. Radioprotective agents and their potential applications.
  6. Comprehensive investigation of the biological effects of both ionizing and non-ionizing radiation.
  7. In-depth exploration of molecular and cellular responses to radiation exposure.
  8. Microenvironment changes after radiation

Dr. Yujie Huang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Radiation is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiobiology
  • ionizing radiation
  • radiation protection
  • radioprotective agent
  • microenvironment
  • radiation exposure
  • radiation safety

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Published Papers (1 paper)

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Research

18 pages, 1494 KiB  
Article
Late Age- and Dose-Related Effects on the Proteome of Thyroid Tissue in Rats after 131I Exposure
by Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z. Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou and Eva Forssell-Aronsson
Radiation 2024, 4(2), 149-166; https://doi.org/10.3390/radiation4020012 - 22 May 2024
Viewed by 1230
Abstract
The physiological process of iodine uptake in the thyroid is used for 131I treatment of thyroid diseases. Children are more sensitive to radiation compared to adults and may react differently to 131I exposure. The aims of this study were to evaluate [...] Read more.
The physiological process of iodine uptake in the thyroid is used for 131I treatment of thyroid diseases. Children are more sensitive to radiation compared to adults and may react differently to 131I exposure. The aims of this study were to evaluate the effects on thyroid protein expression in young and adult rats one year after 131I injection and identify potential biomarkers related to 131I exposure, absorbed dose, and age. Twelve Sprague Dawley rats (young and adults) were i.v. injected with 50 kBq or 500 kBq 131I and killed twelve months later. Twelve untreated rats were used as age-matched controls. Quantitative proteomics, statistical analysis, and evaluation of biological effects were performed. The effects of irradiation were most prominent in young rats. Protein biomarker candidates were proposed related to age, absorbed dose, thyroid function, and cancer, and a panel was proposed for 131I exposure. In conclusion, the proteome of rat thyroid was differentially regulated twelve months after low-intermediate dose exposure to 131I in both young and adult rats. Several biomarker candidates are proposed for 131I exposure, age, and many of them are known to be related to thyroid function or thyroid cancer. Further research on human samples is needed for validation. Data are avaiable via ProteomeXchange with identifier PXD024786. Full article
(This article belongs to the Special Issue Radiation Biology)
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