Precision Psychiatry and Advances in Patient Care: Innovations Transforming the Diagnosis and Treatment of Mental Disorders

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Guest Editor
Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00189 Rome, Italy
Interests: clinical psychiatry; precision psychiatry; clinical psychopharmacology; neuroimaging; genetics
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Guest Editor
Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00189 Rome, Italy
Interests: clinical psychiatry; biological psychiatry; psychopharmacology; pharmacogenomics; neuroimaging in psychiatry; suicidology; clinical psychology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00189 Rome, Italy
Interests: bipolar disorder; weather meteorological changes; sleep-wake rhythm

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Guest Editor
Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy
Interests: mental health; bipolar disorder; schizophrenia; obsessive-compulsive disorder

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Guest Editor
Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy
Interests: biochemistry; genetics and molecular biology; medicine pharmacology; toxicology and pharmaceutics

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a new Special Issue of Psychiatry International, titled "Precision Psychiatry and Advances in Patient Care: Innovations Transforming the Diagnosis and Treatment of Mental Disorders." This Issue invites contributions from our esteemed Editorial Board Members and leading scholars, focusing on developments that are reshaping psychiatric research and clinical care.

Psychiatry is undergoing a crucial transition towards precision approaches that integrate genetic, neurobiological, behavioural, and environmental data to support more accurate, timely, and individualised interventions. This Special Issue will centre on high-burden and complex mental disorders, including major depressive disorder, bipolar disorder, schizophrenia–spectrum disorders, obsessive–compulsive spectrum disorders, and anxiety disorders.

A central focus will be on machine learning and computational psychiatry, which enable the integration of multimodal data—such as neuroimaging, genomics, and digital phenotyping—to identify predictive biomarkers and inform clinical decision-making. Electronic medical record (EMR) databases are also increasingly important, offering large-scale, real-world data for improving diagnostic precision and modelling treatment outcomes. Their integration with computational methods further enhances the potential for personalised care.

In parallel, this Issue will address ethical and implementation challenges, including data privacy, algorithmic bias, and the standardisation of analytic protocols. The goal is to provide a comprehensive overview of the opportunities and limitations of precision psychiatry in clinical practice.

We welcome high-quality original research articles and reviews. Accepted papers will be compiled into a printed volume and actively promoted. We look forward to your contributions to this initiative, which seeks to advance mental health care through innovation and interdisciplinary collaboration.

Dr. Antonio Del Casale
Prof. Dr. Paolo Girardi
Prof. Dr. Carlo Lai
Prof. Dr. Maurizio Simmaco
Dr. Marina Borro
Guest Editors

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Keywords

  • precision medicine
  • psychiatry
  • mental disorders
  • major depressive disorder
  • bipolar disorder
  • schizophrenia spectrum and other psychotic disorders
  • obsessive–compulsive disorder
  • anxiety disorders
  • machine learning
  • electronic health records
  • biomarkers
  • neuroimaging
  • genomics
  • phenotype
  • computational biology

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Published Papers (1 paper)

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8 pages, 218 KB  
Opinion
The Era of Precision Psychiatry: Toward a New Paradigm in Diagnosis and Care
by Antonio Del Casale, Liliana Bronzatti, Jan Francesco Arena, Giovanna Gentile, Carlo Lai, Paolo Girardi, Maurizio Simmaco and Marina Borro
Psychiatry Int. 2025, 6(4), 146; https://doi.org/10.3390/psychiatryint6040146 - 1 Dec 2025
Viewed by 359
Abstract
Mental disorders affect nearly one billion persons worldwide, having a substantial burden on individuals, families, and healthcare systems. Current diagnostic and therapeutic approaches could fail to reach optimal outcomes, highlighting the need for more effective and personalized interventions. Precision psychiatry aims to address [...] Read more.
Mental disorders affect nearly one billion persons worldwide, having a substantial burden on individuals, families, and healthcare systems. Current diagnostic and therapeutic approaches could fail to reach optimal outcomes, highlighting the need for more effective and personalized interventions. Precision psychiatry aims to address this challenge by integrating multidimensional data, ranging from genomics and epigenomics to neuroimaging and psychometric assessments, through advanced computational tools such as machine learning and artificial intelligence. This transdisciplinary approach could allow the study of biologically informed endophenotypes, improve diagnostic accuracy, and support individualized treatment strategies. Emerging technologies, including pharmaco-neuroimaging, virtual histology, and large-scale consortia, are advancing the field by elucidating the molecular and circuit-level correlates of mental disorders. Although significant progress has been made, the translational gap between research and clinical practice remains a critical issue. Effective implementation will require the systematic integration of bioinformatic tools, big data analytics, and clinician-guided interpretation, in a context in which the evolving landscape of precision psychiatry continues to prioritize therapeutic alliance and individualized patient care. Full article
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