Proteomics in Neurodegenerative Diseases
A special issue of Proteomes (ISSN 2227-7382).
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 7846
Special Issue Editor
2. New York University School of Medicine, New York, NY 10016, USA
Interests: Alzheimer’s disease; frontotemporal dementia; proteomics; neuropathology; protein-protein interactions
Special Issue Information
Dear Colleagues,
Proteomics provides an incredibly exciting path forward for our understanding of neurodegenerative diseases. The causes of major neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia are still unknown and studies suggest that complex, intersecting disease mechanisms are involved. Proteomics is an ideal method to understand the complex pathogenesis of neurodegenerative diseases and to identify new biomarkers and therapeutic targets. It also provides an excellent opportunity to explore the pathological role that particular post-translational modifications and protein–protein interactions have in neurodegenerative diseases. Exciting recent methodological advances have allowed the examination of disease-associated protein differences with unprecedented sensitivity, and have permitted the examination of highly localized disease-associated protein changes in specific cell types, subcellular fractions or in neuropathological lesions.
This Special Issue welcomes submissions of original research, method papers, and review articles that focus on the use of proteomics approaches to study neurodegenerative disease. We are especially interested in articles that use proteomics to profile disease-associated protein interactions or post-translational modifications, and that use proteomics approaches to profile localized protein differences present in particular regions, fractions, cell types, or neuropathological lesions. We are also particularly interested in studies that use proteomics to identify novel biomarkers for neurodegenerative disease and studies that discuss new bioinformatics approaches to study this rapidly expanding field of neurodegenerative disease proteomics.
Dr. Eleanor Drummond
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.
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Keywords
- Neurodegenerative disease
- Neuroproteomics
- Mass spectrometry
- Quantitative proteomics
- Protein-protein interaction
- Neuropathology
- Post-translational modifications
- Biomarkers
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