Quantitative Deep Proteomics

Dear Colleagues,

A new era in proteomics research has begun. Novel approaches to quantify and identify thousands of proteins from a single biological sample are being developed and applied. While not too long ago, proteomics was only scratching the “tip of the iceberg”, novel methods nowadays provide comprehensive and quantitative views of the proteomes of living cells, organelles, organs, and tissues. In fact, multiple new methods are now on par with analogous deep sequencing methods in genomics and transcriptomics, and are hence collectively referred to as “deep proteomics”. Biological events not only give rise to varying levels of proteins within cellular compartments or extracellular secretions, rapid cellular responses also alter protein posttranslational modifications (PTMs), such as phosphorylation, ubiquitinylation, glycosylation, and many others. Deciphering protein-based responses on a holistic scale allows scientists to understand complicated regulatory networks of life on an unrepresented level.

We invite you to contribute original research, technical notes, methods papers, and reviews on the subject of “Deep Quantitative Proteomics” as well as on the large scale associated characterization of protein phosphorylation, other PTMs, protein isoforms, and proteogenomics to this Special Issue. Research that combines advances in mass spectrometric instrumentation with cleverly designed biological experimentation and advanced bioinformatics methods to provide deep proteomics insights into biological systems will be appreciated by our readership and will be highlighted as important and significant advancements of proteomic science.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Quantitative proteomics
• Deep proteomics
• Posttranslational Protein Modifications
• Protein Phosphorylation
• Mass Spectrometry
• LC/MS
• Systems biology
• Proteome bioinformatics