New Insights into Polysaccharide-Based Scaffolds: Design, Production and Applications

A special issue of Polysaccharides (ISSN 2673-4176).

Deadline for manuscript submissions: 1 August 2026 | Viewed by 1203

Special Issue Editor


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Guest Editor
Laboratory of Bioinspired Materials (LABIM), Department of Science, University of Basilicata, 85100 Potenza, Italy
Interests: polysaccharides; biopolymers; biomaterials; electrospinning; glycosaminoglycans
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Special Issue Information

Dear Colleagues,

Natural and synthetic polysaccharides represent intriguing candidates as scaffolding materials for biomedical and technological applications, ranging from tissue engineering, drug delivery, and biosensing to energy storage. Polysaccharide macromolecules consist of monosaccharide units connected by glycosidic bonds with functional groups on the polymeric backbone, enabling structural modifications. This feature, together with their biodegradability, biocompatibility, and non-toxicity aspects, encourages the investigation of these biopolymers. This Special Issue aims to highlight the recent advances in the area of scaffolds, with a particular interest in the design, production characterization and performance evaluation of those containing native or suitably functionalized polysaccharides for tissue engineering and biomedical applications. Depending on the design, topics include (but are not limited to) hydrogels and porous, fibrous, and composite scaffolds. Fabrication method topics may pertain to solvent casting, phase separation, electrospinning, freeze-drying, 3D printing, etc.

Dr. Antonio Laezza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polysaccharides is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polysaccharides
  • scaffolds
  • biomaterials
  • structural functionalization
  • tissue engineering

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Published Papers (1 paper)

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Review

27 pages, 2211 KB  
Review
Changed Characteristics of Bacterial Cellulose Due to Its In Situ Biosynthesis as a Part of Composite Materials
by Elena Efremenko, Nikolay Stepanov, Aysel Aslanli, Olga Maslova, Ivan Chumachenko, Olga Senko and Amrik Bhattacharya
Polysaccharides 2025, 6(4), 114; https://doi.org/10.3390/polysaccharides6040114 - 14 Dec 2025
Viewed by 269
Abstract
In recent years, the sustained and even increasing interest in the development and application of novel composite materials based on the polysaccharide bacterial cellulose (BC) has been driven by the accumulation of experimental data and the emergence of analytical reviews that narratively summarize [...] Read more.
In recent years, the sustained and even increasing interest in the development and application of novel composite materials based on the polysaccharide bacterial cellulose (BC) has been driven by the accumulation of experimental data and the emergence of analytical reviews that narratively summarize these findings. This review presents a comparative and critical analysis of various approaches to the fabrication of BC-based composites. Among them, in situ biosynthesis is highlighted as the most promising strategy. In this approach, different additives are introduced directly into the culture medium of BC-producing microorganisms, enabling the formation of materials with different mechanical and physicochemical properties. Such a method also allows imparting to the composites a range of properties that BC itself does not possess, including antibacterial and enzymatic activity, as well as electrical conductivity. During the so-called “cell weaving” stage, performed by BC-producing microorganisms, diverse substances and microorganisms can be incorporated into the cultivation medium. By varying the concentrations of the introduced compounds, their ratios to the synthesized BC, and by employing different BC-producing strains and substrates, it becomes possible to regulate the characteristics of the resulting composites. Special attention is given to the role of various polysaccharides that are either introduced into the medium during BC biosynthesis or co-synthesized alongside BC within the same environment. Depending on the mode of incorporation of these additional polysaccharides, the resulting materials demonstrate variations in Young’s modulus and tensile strength. Nevertheless, they almost invariably exhibit a decreased degree of BC crystallinity within the composite structure and an enhanced water absorption capacity compared to the pure polymer. Full article
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