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Natural Biopolymers for Biomedical Applications

A Special Issue of Polymers (ISSN 2073-4360) belonging to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 2027

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Biochemistry Division, Department of Chemistry, Faculty of Science, Dokuz Eylul University, 35210 Izmir, Türkiye
Interests: polymers; synthesis; characterization; gels; rheology; thermal properties; drug delivery; coating; emulsions; composites; nanocomposites
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Special Issue Information

Dear Colleagues,

The search for sustainable alternatives to petroleum-derived products has accelerated research into the biosynthesis, design, and characterization of materials from natural resources. Plant-based polymers, lignocellulosic biomass, natural fibers, proteins, polysaccharides, and mineral or microbial compounds represent abundant and renewable sources with significant potential for high-value applications. Biosynthetic approaches, particularly microbial fermentation and enzymatic catalysis, enable the conversion of natural feedstocks into bioplastics, nanocellulose, bioceramics, and bioactive compounds while reducing environmental impact. Advances in biotechnology, including genetic and metabolic engineering, also allow the fine-tuning of structural and functional properties to meet specific performance demands. In parallel, rational design principles supported by computational modeling and structure–property analyses are being used to create bio-derived materials with tailored mechanical, optical, catalytic, and biomedical characteristics. Equally important is the role of advanced characterization techniques—ranging from spectroscopy and microscopy to thermal and surface analysis—in assessing morphology, crystallinity, porosity, and stability, ensuring reproducibility and scalability. These insights bridge the gap between biosynthesis and practical applications in fields such as energy storage, drug delivery, tissue engineering, water purification, and environmental remediation. By integrating biotechnology, chemistry, and materials science, the development of natural-resource-based materials aligns closely with the principles of a circular economy and global sustainability goals. This Special Issue aims to highlight recent progress in biosynthetic strategies, innovative design approaches, and rigorous characterization methods, showcasing how renewable resources can inspire multifunctional systems for a greener and more resilient future.

Dr. Catalina Natalia Cheaburu-Yilmaz
Guest Editor

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Keywords

  • biopolymers
  • nanocellulose
  • lignocellulosic biomass
  • polylactic acid (PLA)
  • microbial biosynthesis
  • green chemistry
  • bioceramics
  • natural fibers
  • bioactive compounds
  • tissue engineering
  • drug delivery
  • circular economy
  • sustainable materials
  • biotechnologicy

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Published Papers (2 papers)

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Research

14 pages, 4737 KB  
Article
Fabrication, Simulation, and Mechanical Characterization of Curcumin-Loaded PVA/PVP Microneedle Arrays Using Custom 3D-Printed Molds
by Bryan Angelo S. J. Basa, Charlize Dawn Z. Batin, Izabelle Nisha Maxine D. Chan, Adrian Ray B. Gabay, John Ray C. Estrellado, Ron Gilbert R. Rallos, Mary Stephanie S. Carranza, Mark Jefferson U. Lim, Jubert C. Marquez and Joseph Rey H. Sta Agueda
Polymers 2026, 18(15), 1912; https://doi.org/10.3390/polym18151912 - 4 Aug 2026
Viewed by 810
Abstract
Microneedle (MN) arrays offer a novel and minimally invasive platform for transdermal drug delivery. This study presents an approach for the design and fabrication of MN array models for biomedical applications using custom 3D-printed micro-molds. Material analysis of the polyvinyl alcohol (PVA) and [...] Read more.
Microneedle (MN) arrays offer a novel and minimally invasive platform for transdermal drug delivery. This study presents an approach for the design and fabrication of MN array models for biomedical applications using custom 3D-printed micro-molds. Material analysis of the polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) matrix in a 3:1 weight ratio was conducted under varying geometric configurations, curcumin (CUR) dosages, and target penetration depths of 300 to 500 μm. Computational simulation using computer-aided design (CAD) and finite element analysis (FEA) on ANSYS (Canonsburg, PN, USA) measured for total deformation, stress distribution, insertion pressure, and factor of safety. Elimination criteria were applied, narrowing down to specific models that were experimentally validated through material formulation, micro-molding, and material characterization. The selected MN models were analyzed by insertion and penetration efficiency testing on porcine skin. The results showed that higher CUR concentrations reduced mechanical strength and Young’s modulus, while mid-range dosages (2–6 mg) combined with optimized geometric spacing produced MNs with maintained structural integrity and effective performance. Conical microneedles demonstrated the most favorable balance of mechanical stability, controlled swelling behavior, and high insertion efficiency. The study recommends this approach as a feasible and reproducible method for localized wound-healing applications. Full article
(This article belongs to the Special Issue Natural Biopolymers for Biomedical Applications)
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16 pages, 2234 KB  
Article
Gelatin–St. John’s Wort Oil Matrices: Material Properties for Potential Biomedical Applications
by Mehlika Karamanlioglu
Polymers 2026, 18(11), 1360; https://doi.org/10.3390/polym18111360 - 30 May 2026
Viewed by 843
Abstract
This study investigates physicochemical, mechanical, and thermal effects of St. John’s wort (JW) oil on gelatin-based films for potential biomedical applications as there is limited research on gelatin biomaterials containing JW oil as sole bioactive component. Transparent films were fabricated at gelatin:JW oil [...] Read more.
This study investigates physicochemical, mechanical, and thermal effects of St. John’s wort (JW) oil on gelatin-based films for potential biomedical applications as there is limited research on gelatin biomaterials containing JW oil as sole bioactive component. Transparent films were fabricated at gelatin:JW oil ratios of 20:0, 20:1, 20:5 (w/w) designated as JW-0, JW-1, JW-2, respectively, via solution casting. Gas chromatography revealed that JW oil is rich in unsaturated fatty acids, predominantly linoleic and oleic acids, while FTIR confirmed their successful integration into the gelatin matrix through the fatty acid peak at 1743 cm−1. Oil droplets, increasing with oil content was shown by SEM. JW oil improved water durability by reducing water aging by up to 8%. JW oil acted as a plasticizer, raising elongation at break (EAB) from 188% in JW-0 to 231% and 209% in JW-1 and JW-2, respectively. DSC indicated a higher Tmax in JW-1 (116 °C) compared to JW-2 (110 °C), evidencing better thermal stability. In conclusion, JW oil can be effectively incorporated into gelatin as a single active component. Specifically, JW-1 formulation achieved an optimal balance between mechanical and structural integrity, flexibility, and thermal stability, underscoring its potential as a cost-effective, bioactive wound dressing material. Full article
(This article belongs to the Special Issue Natural Biopolymers for Biomedical Applications)
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