The Advances of Cold Plasma in the Biomedicines

A special issue of Plasma (ISSN 2571-6182).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2782

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Department of Oral Anatomy, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Interests: tissue regeneration; cancer treatment; detal treatment; plasma medical device
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Special Issue Information

Dear Colleagues,

Plasma used in industrial fields requires a vacuum state and has a characteristic of generating high heat. When the temperature of the plasma is less than 250 degrees Celsius, it is called low-temperature plasma. In order to be treated on human tissues, the temperature of the plasma must be less than 40 degrees Celsius. In that respect, it has recently been referred to as Cold Plasma. The definition of plasma used in the biomedical field seems to be more appropriate for cold plasma than for low-temperature atmospheric pressure plasma or non-thermal plasma. Therefore, in this Special Issue, I look forward to the unified usage of the term “cold plasma”.

Plasma medicine, which started when cold plasma was applied to bacteria and cells, has made much progress for nearly 20 years. The scope of plasma research is expanding from just killing pathogens and cancer cells to tissue regeneration and selective cancer cell death. Among the numerous constituents of plasma, studies on which ones have medical functions and the mechanisms by which plasma-induced biomedical phenomena depend on are being actively conducted. Plasma medical devices are being developed based on these studies, and it is expected that various plasma medical devices will be introduced to the medical market in the near future.

In the current research climate, this Special Issue, as the joint special issue (https://www.mdpi.com/journal/biomedicines/special_issues/Plasma_Biomedicines) with our sister journal /Biomedicines/ (ISSN 2227-9059), calls for all advanced plasma medicine research including various life phenomena induced by plasma. Experimental as well as review papers consistent with this research topic are welcome.

Prof. Dr. Gyoocheon Kim
Guest Editor

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Keywords

  • cold plasma (non-thermal plasma, low temperature plasma)
  • pathogen sterilization
  • regeneration
  • disease treatment
  • medical device
  • biomaterial

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Published Papers (1 paper)

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Research

10 pages, 1616 KiB  
Communication
Extracellular Heat Shock Protein 27 Is Released by Plasma-Treated Ovarian Cancer Cells and Affects THP-1 Monocyte Activity
by Debora Singer, Can Pascal Wulff, Matthias B. Stope and Sander Bekeschus
Plasma 2022, 5(4), 569-578; https://doi.org/10.3390/plasma5040040 - 6 Dec 2022
Cited by 2 | Viewed by 1997
Abstract
Heat shock protein 27 (Hsp27) is a cytoprotective molecule and is inducible via oxidative stress. Anti-cancer therapies, such as the recently investigated gas plasma, subject tumor cells to a plethora of reactive oxygen species (ROS). In ovarian tumor microenvironments (TME), immune cells such [...] Read more.
Heat shock protein 27 (Hsp27) is a cytoprotective molecule and is inducible via oxidative stress. Anti-cancer therapies, such as the recently investigated gas plasma, subject tumor cells to a plethora of reactive oxygen species (ROS). In ovarian tumor microenvironments (TME), immune cells such as monocytes and macrophages can be found in large numbers and are often associated with cancer progression. Therefore, we quantified extracellular Hsp27 of OVCAR-3 and SK-OV-3 cells after gas plasma exposure in vitro. We found Hsp27 to be significantly increased. Following this, we investigated the effects of Hsp27 on THP-1 monocytes. Live cell imaging of Hsp27-treated THP-1 cells showed decelerated cell numbers and a reduction in cell cluster sizes. In addition, reduced metabolic activity and proliferation were identified using flow cytometry. Mitochondrial ROS production decreased. Using multicolor flow cytometry, the expression profile of eight out of twelve investigated cell surface markers was significantly modulated in Hsp27-treated THP-1 cells. A significantly decreased release of IL18 accommodated this. Taken together, our results suggest an immunomodulatory effect of Hsp27 on THP-1 monocytes. These data call for further investigations on Hsp27’s impact on the interplay of ovarian cancer cells and monocytes/macrophages under oxidative stress conditions. Full article
(This article belongs to the Special Issue The Advances of Cold Plasma in the Biomedicines)
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