Advances in Formulation of Nanocarriers for Overcoming Biological Barriers

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1515

Special Issue Editor


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Guest Editor
Pharmaceutical Science Graduate Program, Federal University of Pampa—UNIPAMPA, Uruguaiana 97501-970, Brazil
Interests: nanobiotechnology; pharmaceutical technology; preclinical pharmacokinetics; pharmacokinetics modeling; biopharmaceutics

Special Issue Information

Dear Colleagues,

Nanocarriers have shown a considerable advantage in increasing the biological performance of drugs, revolutionizing nanomedicine. For their application, nanocarriers should be transported by the human body, overcoming physiological barriers, such as mucosal, epithelial, or intracellular, to achieve precision drug delivery.

To design nanocarriers we should consider not only physiological barriers but also the pathological state, which restructures tissue properties, such as inflammation or the tumor microenvironment, demanding new strategies for drug targeting in this modified biophase.

Therefore, in this Special Issue, we plan to collect the latest advances in new nanocarriers, aiming to overcome the physiological/pathological barriers and to describe their formulation, pharmacokinetics, toxicology, and biological targets.

Dr. Sandra Elisa Haas
Guest Editor

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Keywords

  • biological barriers
  • drug delivery
  • nanocarriers
  • pharmacokinetics
  • toxicology
  • pharmacodynamics

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Published Papers (1 paper)

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Research

14 pages, 1255 KiB  
Article
Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in Plasmodium berghei-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling
by Tamara Ramos Maciel, Ana Claudia Funguetto-Ribeiro, Laura Ben Olivo, Flávia Elizabete Guerra Teixeira, Camila de Oliveira Pacheco, Bibiana Verlindo de Araujo and Sandra Elisa Haas
Pharmaceutics 2024, 16(11), 1369; https://doi.org/10.3390/pharmaceutics16111369 - 25 Oct 2024
Viewed by 935
Abstract
Objectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in WB using Plasmodium berghei-infected mice, with a subsequent [...] Read more.
Objectives: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in WB using Plasmodium berghei-infected mice, with a subsequent model comparison for nanocapsules coated with polysorbate (NCP80) or prepared with Eudragit® RS (NCEUD). The WB quinine population pharmacokinetic model in rats was developed using plasma and partition coefficients for rat erythrocytes. Mouse WB quinine population PK/PD modeling was developed using allometrically scaled literature-free mouse quinine pharmacokinetic data and covariate values to obtain a WB population pharmacokinetic model for quinine and nanocapsules in mice. This allowed for PK/PD modeling of the quinine population with the WB concentration and parasitemia data in mice. All models were built in NONMEN. Results: The WB quinine concentration profiles in rats were characterized using a two-compartment model. Nanoencapsulation reduced clearance and central compartment volume and increased peripherical compartimental volume. A maximum effect model described the PK/PD of the quinine WB population in mice, demonstrating that NCEUD enhances the antimalarial effect. Conclusions: Quinine WB is a good surrogate for describing the response to exposure in malaria. NCEUD outperformed NCP80 and free quinine, suggesting that cationic surfaces improve the potential for treating malaria. Full article
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