Delivery of Oligonucleotide Therapeutics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 193

Special Issue Editors


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Guest Editor
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy
Interests: oligonucleotide aptamers; oligonucleotide analogs; nucleopeptides; metal-based drugs; DNA-small molecule interaction; DNA-protein interaction
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Guest Editor
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy
Interests: noncanonical nucleic acids; nucleic acid theranostics; small molecule–DNA interactions

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Guest Editor
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
Interests: noncanonical nucleic acids; cellular and molecular biology; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oligonucleotide therapeutics (OTs) are synthetic DNA or RNA strands with the potential to treat a wide range of diseases. OTs include several molecular entities, such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), anti‐microRNAs (antagomirs), microRNA mimics (agomirs), aptamers and unmethylated CpG‐containing oligonucleotides.

Until now, fifteen FDA-approved oligonucleotide drugs have been released on the market, with many other OTs being investigated.

OTs are promising candidates in the pharmaceutical context. Nevertheless, one of the greatest challenges in oligonucleotide therapy is the delivery of the active substances to the site of action, mainly due to their unfavorable pharmacokinetic profile and nuclease degradation.

To overcome these issues, many strategies have been reported in the literature, ranging from chemical modifications of the DNA/RNA backbone to bioconjugation or encapsulation in nanocarriers.

The continuous progress in this field is gradually unlocking the true potential of oligonucleotide-based therapeutics, opening new perspectives and expanding the range of possible applications.

Authors are invited to submit original papers, communications and reviews regarding the delivery of oligonucleotide therapeutics, to be published in this Special Issue of Pharmaceutics.

Dr. Domenica Musumeci
Dr. Ettore Napolitano
Dr. Anna Di Porzio
Guest Editors

Manuscript Submission Information

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Keywords

  • DNA
  • RNA
  • oligonucleotides
  • nucleic acid-based therapeutics
  • drug delivery
  • biodistribution
  • pharmacokinetic

Published Papers

This special issue is now open for submission.
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