Special Issue "Targeting Cell Junctions for Therapy and Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 20 October 2022 | Viewed by 310

Special Issue Editors

Dr. Brian Belardi
E-Mail Website
Guest Editor
McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA
Interests: cell contact and adhesion; extracellular matrix; synthetic biology; chemical biology; therapeutics; biophysics
Prof. Dr. Michael Koval
E-Mail Website
Guest Editor
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Interests: intercellular interactions; tight junctions; integrins; super-resolution microscopy; nanotechnology; epithelial cells

Special Issue Information

Dear Colleagues,

I am pleased to invite you to submit manuscripts for a Special Issue in Pharmaceutics, focused on targeting cell junctions for therapy and delivery. Cell junctions integrate cells within a tissue, enabling long-range communication, collective action, tissue surveillance, and protective maintenance. Beyond mere connections, junctions have recently emerged as critical hubs for cellular decision-making functions, with dysfunctional organization and interactions leading to disease progression and cell death. This Special Issue highlights work on the frontier of designing molecules, materials, and interventions that target junctional components and their cellular organization. In doing so, junctions can be manipulated to reinforce their integrity or disrupt their function. The latter is particularly important for improving the delivery of therapeutics to their site of action. The articles that belong to this issue will showcase how junctions can be manipulated for therapeutic purposes and how delivery can be improved.

This Special Issue aims to highlight new pharmaceutical methodologies and materials which alter the junctional state, both directly—by acting on junctional molecules—and indirectly—by causing cell-wide responses. The scope of the issue also encompasses research on optimized assays for characterizing the state of junctions and their function within tissue. Both original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Brian Belardi
Prof. Dr. Michael Koval
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • barrier function
  • adhesion
  • permeability
  • cell Junctions
  • membrane receptors
  • membrane trafficking
  • cytoskeleton attachment
  • mechanotransduction
  • biologics
  • nanotechnology

Published Papers

This special issue is now open for submission.
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