Pharmaceutical Manufacturing Process of Inhaled Drugs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (25 May 2024) | Viewed by 4585
Special Issue Editor
Special Issue Information
Dear Colleagues,
An inhalation preparation refers to a special dosage form that is administered with a special device, such that a drug acts on the lungs and exerts local or systemic effects through the deep part of the respiratory tract, cavities, mucous membranes, etc. It is often used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease. The route of inhalation administration has the advantages of being non-invasive, a quick onset, less local metabolic enzymes, and localized drug delivery. According to different devices, it can be divided into powder inhalations (DPIs), metered inhalation aerosols (MDIs), and liquid preparations for inhalation. Additionally, there are inhalation sprays, among which DPIs, MDIs, and liquid preparations for inhalation are widely used. In recent years, with increasing air pollution and the aging of the population, the prevalence of respiratory diseases continues to rise, and inhalation drug delivery has become a method of drug delivery that has attracted much attention. In addition, inhalation formulations for the delivery of novel biologics for pulmonary disorders, infections, and cancer, such as mRNA, antibodies, and diagnostics, have received extensive attention from academia and industry.
The preparation methods of respirable particles include top-down techniques and bottom-up techniques. Traditional drug grinding methods include ball milling, colloid milling, hammer milling, and jet milling. In this Special Issue, we will focus on novel laboratory as well as industrial methods for formulating generic drugs and novel therapeutic cargos.
Dr. Qian Zhong
Guest Editor
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Keywords
- inhaled drug
- respiratory system
- nanoparticles
- spray drying
- spray freeze
- powder inhalation (DPI)
- metered inhalation aerosol (MDI)
- mRNA
- biologics
- pulmonary diseases
- cancer
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