Model-Informed Precision Dosing in Drug Development and Clinical Practice
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 278
Special Issue Editors
Interests: pharmacometrics; clinical pharmacology; therapeutic drug monitoring; model-informed precision dosing; inflammatory bowel diseases; monoclonal antibody therapies
Interests: drug metabolism; drug delivery; nanotechnology; pharmacogenomics; toxicology; transcriptional regulation
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Special Issue Information
Dear Colleagues,
Population pharmacokinetics–pharmacodynamics (popPK–PD) models play an increasingly important role in optimizing drug dosing across both drug development and clinical settings. These pharmacometric models are central to model-informed precision dosing (MIPD), which enables individualized therapy by incorporating patient-specific characteristics and addressing variability in drug exposure and response. Ultimately, MIPD promotes pharmacoequity by helping ensure that every patient has the best possible chance of benefiting from treatment while maximizing therapeutic outcomes.
I am pleased to invite you to contribute original research articles, reviews, and methodological papers to this Special Issue entitled “Model-Informed Precision Dosing in Drug Development and Clinical Practice”. This collection aims at showcasing recent advances in MIPD, with a focus on drug development and clinical implementation—particularly in special populations and therapeutic areas where individualized dosing is essential. The scope includes, but is not limited to, methodological developments in pharmacometrics modeling and simulation; pharmacometric model-informed drug development; MIPD implementation in clinical practice; challenges in model validation and translation; and innovations in Bayesian forecasting and decision support tools.
We look forward to your submissions and to highlighting the expanding impact of MIPD in drug development and clinical practice.
Dr. Zhigang Wang
Prof. Dr. Bingfang Yan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- model-informed precision dosing (MIPD)
- efficacy PKPD indexes
- pharmacokinetics
- pharmacodynamics
- PKPD modeling and simulation
- dosing algorithms
- nomograms
- drug development
- therapeutic drug monitoring (TDM)
- dosing adjustments
- special populations
- nonlinear mixed-effects modeling (NONMEM)
- PK/PD models
- drug–drug interactions
- pediatrics
- pregnancy
- oral bioavailability
- modelling and simulation
- population pharmacokinetics
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