Pharmacokinetic and Pharmacodynamic Considerations for Drugs Used in the Treatment of Cardiovascular Diseases
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 3797
Special Issue Editors
Interests: pharmacokinetics; pharmacodynamics; pharmacology; stroke research; inflammation; imaging
Special Issue Information
Dear Colleagues,
Current considerations in pharmacokinetics and pharmacodynamics for cardiovascular drugs include personalized medicine, drug–drug interactions, comorbidity considerations, and innovative drug delivery systems. These factors collectively contribute to optimizing treatment outcomes and patient safety in the management of cardiovascular diseases, which we would like to touch on this Special Issue of Pharmaceutics.
Pharmacokinetic and pharmacodynamic considerations play a crucial role in the effective treatment of cardiovascular diseases and several noteworthy considerations have emerged.
One current consideration in the field of pharmacokinetics is the potential for drug–drug interactions at different levels of ADME. In terms of pharmacodynamics, current considerations include investigating drugs that target specific pathways involved in cardiovascular disease, such as inflammation and thrombosis. Additionally, there is a growing interest in personalized medicine, which involves tailoring drug therapy to an individual's physiological characteristics such as age, gender, and renal and hepatic function, as well as genetic factors. Advancements in pharmacogenomics have highlighted the importance of genetic variations in drug response. Genetic testing can identify individuals at increased risk of adverse effects or non-response to certain cardiovascular medications, allowing for personalized treatment plans. The impact of comorbidities on pharmacokinetics and pharmacodynamics is also gaining attention. Conditions such as liver disease, renal impairment, and heart failure can significantly alter drug metabolism and distribution, requiring dose adjustments or alternative treatment strategies. Lastly, advancements in drug delivery systems, such as targeted drug delivery, have the potential to enhance drug efficacy, reduce dosing frequency, and improve patient compliance.
Dr. Noriko Daneshtalab
Dr. Reza Tabrizchi
Guest Editors
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Keywords
- pharmacokinetics
- pharmacodynamics
- cardiovascular diseases
- drug-drug interaction
- targeted drug delivery
- pharmacogenomics
- co-morbidity
- personalized medicine
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