Blood–Brain Barrier Drug Targeting: The Future of Brain Drug Development, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 11000
Special Issue Editor
Interests: blood–brain barrier; pain therapeutics; drug delivery; drug development; CNS targeting
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurological disorders have been a challenge to target therapeutically given the presence of the blood–brain barrier (BBB). Blood–brain barrier (BBB)/Neurovascular unit (NVU) integrity is vital to the health of the central nervous system (CNS) and serves as the gateway for CNS drug delivery. However, the influence of pathological changes on BBB dynamics and ultimately on brain drug development is oft overlooked. Thus, it is important to the clinical success of new CNS-targeting agents to account for pathological changes, as well as those resulting from aging and sex differences, to fully understand BBB integrity, its impact on drug delivery, and how these issues will be addressed in the future.
The aim of this Special Issue of Pharmaceutics is to collect research and review papers on targeting the CNS during disease by understanding the role of the BBB in drug discovery and development. We welcome articles dealing with any aspect of BBB dynamics during physiological and pathophysiological states on CNS drug delivery and invite researchers and drug developers to publish their original research or review articles with expert opinions and perspectives in the area of therapeutics.
Dr. Tally Largent-Milnes
Guest Editor
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Keywords
- blood–brain barrier
- drug delivery
- CNS targeting
- drug development
- pathologic influence on the neurovascular unit
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