3D Models for Cancer: From 3D Technology to Personalized Medicine
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 616
Special Issue Editor
Special Issue Information
Dear Colleagues,
I am editing this new Special Issue in Pharmaceutics focusing on “3D Models for Cancer: From 3D Technology to Personalized Medicine”.
The advent of 3D cell culture techniques has provided scientists and clinicians with a new weapon to fight cancer and opened new possibilities for the development of personalized therapies. Indeed, the combination of this new tool and technology with biomaterials has allowed the evolution from 2D to 3D in vitro models, such as spheroids, scaffold-based cultures, and bioprinted systems, which finely mimic both cancer and the tumor microenvironment. This offers scientists a more realistic understanding of cancer biology other than a reduction in the use of animal systems. In the context of anticancer strategies, 3D models could find large applications in the field of drug discovery, accelerating the drug development process. In fact, they better resemble in vivo features, such as cell to cell and cell to ECM interactions, cell spatial organization in organs, cell morphology, and cell receptor expression, which are involved in drug accessibility and interaction with target cells and thus determine the drug response. In addition, the use of the newest 3D technologies, such as 3D bioprinting, allow performing high-throughput screening of different treatment strategies, ensuring high reproducibility and affordability as well as a reduction in time, costs, and in the use of animal models. Meanwhile, the utilization of patient-derived cancer cells in 3D systems makes it possible to create personalized disease models, enabling the development of personalized treatment regimens.
Despite this, the powerfulness in the use of 3D models for the development of cancer treatment is threatened by the high variability between different systems and laboratory practices. For this reason, the purpose of this Special Issue is not just to serve as a comprehensive overview of recent advances in 3D modeling for cancer treatment, but to provide a platform where scientists can exchange useful practical information, report their main research issues, and share their discoveries.
Dr. Marta Canta
Guest Editor
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Keywords
- cancer models
- 3D printing
- scaffold based techniques
- drug screening
- cancer biology
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