Formulations for Anti-Inflammatory Efficacy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 330

Special Issue Editor


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Guest Editor
Department of Biological and Health Sciences, University of Araraquara (UNIARA), Rua Carlos Gomes, 1338—Centro Araraquara, São Paulo 14801-340, Brazil
Interests: pharmaceutical and cosmetic formulations; pharmacy; pharmacotechnics; cosmetology; cosmetics

Special Issue Information

Dear Colleagues,

Anti-inflammatories are a class of drugs widely used in medical practice due to the fact that the inflammatory process is a central pathophysiological mechanism in numerous diseases, both acute and chronic. Proper control of this process is essential to preserve tissue function and the patient's quality of life.

Effectiveness in the control of inflammatory mechanisms requires more than just active ingredients; efficient pharmaceutical formulations are essential, as they directly influence therapeutic efficacy, the safety of the prepared medication, and patient adherence.

Therefore, this special edition focuses on this issue, aiming to understand updates on innovative formulations and technologies capable of increasing efficacy, safety, and patient adherence to the use of such medications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Novel synthetic antiinflamatory actives;
  2. Novel anti-inflammatory bioactives;
  3. Development of oral anti-inflammatory formulations;
  4. Development of topical anti-inflammatory formulations;
  5. Development of parenteral anti-inflammatory formulations;
  6. New methodologies to evaluate anti-inflammatory formulations.

Dr. Bruna Chiari-Andréo
Guest Editor

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Keywords

  • inflammation
  • steroidal anti-inflammatory drugs
  • non-steroidal anti-inflammatory drugs
  • natural anti-inflammatory drugs
  • efficacy and safety.

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Published Papers (1 paper)

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Research

19 pages, 7288 KB  
Article
Influence of Impregnation Conditions on Tenoxicam Solubility and Loading into γ-Cyclodextrin Metal–Organic Frameworks: A Box–Behnken Design Approach
by Lubna Y. Ashri, Mohamed Abbas Ibrahim, Dalal Alezi, Dalia H. Almasud, Atheer A. Alnasiri, Deema N. Alsultan, Nouf Alhaqbani, Asail Y. Bopsheet, Raja R. Jamalaldeen, Meshal K. Alnefaie, Nojoud Al Fayez, Doaa Hasan Alshora, Rihaf Alfaraj and Bushra T. AlQuadeib
Pharmaceutics 2026, 18(2), 206; https://doi.org/10.3390/pharmaceutics18020206 - 5 Feb 2026
Viewed by 126
Abstract
Background/Objectives: γ-Cyclodextrin metal–organic frameworks (γ-CD-MOFs) are biocompatible porous crystalline materials that combine the advantages of both γ-cyclodextrins (γ-CDs) and MOFs, making them promising carriers for drug delivery. However, drug loading efficiencies into γ-CD-MOFs achieved by impregnation method involves complex interactions that necessitate [...] Read more.
Background/Objectives: γ-Cyclodextrin metal–organic frameworks (γ-CD-MOFs) are biocompatible porous crystalline materials that combine the advantages of both γ-cyclodextrins (γ-CDs) and MOFs, making them promising carriers for drug delivery. However, drug loading efficiencies into γ-CD-MOFs achieved by impregnation method involves complex interactions that necessitate further systematic exploration. This study aimed to determine the impregnation conditions that significantly impact tenoxicam (TNX) loading into γ-CD-MOFs and its aqueous solubility, and to identify the optimal possible conditions for maximizing both. Methods: A three-factor, three-level (33) Box–Behnken factorial design technique was utilized. Results: Statistical analysis showed that TNX/γ-CD-MOF molar ratio exerted a significant positive effect on drug loading, whereas loading temperature and time have an insignificant effect. Additionally, while loading TNX into γ-CD-MOFs increased its water solubility, variations in the loading parameters did not produce a significant effect on this solubility. The impregnation conditions obtained from the numerical optimization step were a drug/MOF molar ratio of 1.99:1 at 29 ± 0.5 °C for 6 h, which experimentally showed TNX loading of 12.2 ± 1.55%. A discrepancy between the predicted and experimental drug-loading results was observed suggesting that the fitted model does not fully capture the complexity of the system, highlighting the need for experimental verification. Conclusions: This work delivers new insights into the impregnation factors governing TNX loading into γ-CD-MOFs and establishes a foundational framework for the future optimization of CD-MOFs-based drug formulations. Full article
(This article belongs to the Special Issue Formulations for Anti-Inflammatory Efficacy)
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