Drug Stability in Oral Administration
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 128
Special Issue Editors
Interests: in-use drug stability; diabetes management; nutraceuticals
Special Issue Information
Dear Colleagues,
The oral route of drug administration is the most preferred route of drug delivery due to patient preference and the cost-effectiveness of manufacturing. However, the stability of the active pharmaceutical ingredient and the formulation can significantly impact drug absorption and bioavailability. Drug stability can be defined as the extent to which an active pharmaceutical ingredient (API) or formulation remains within specified limits during storage and use. Drug stability can be affected by many factors, including but not limited to formulation and packaging, administration, and in vivo conditions. Therefore, understanding and ensuring the stability of an API and the dosage form are critical to the quality, safety, and efficacy of a pharmaceutical formulation. In recent years, various innovative strategies have been used to optimize drug stability in oral administration, such as encapsulation techniques, embedding in nanostructured polymers, particle engineering, and the use of advanced drug delivery systems.
The aim of compiling this Special Issue of Pharmaceutics on the topic of “Drug Stability in Oral Administration” is to explore multifaceted challenges and innovations in the field of oral drug delivery and to bring together cutting-edge research on novel techniques of stability enhancement and insights into the stability of novel therapeutic agents delivered via the oral route (e.g., peptides and proteins).
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Physicochemical stability of oral drug formulations;
- Off-label modification of oral drug formulations;
- New techniques of stability enhancement;
- Stability of protein and peptide therapeutics;
- Effect of food on drug stability;
- The use of in situ methods for drug stability and release;
- Impact of excipients;
- In-use drug stability.
Dr. Thilini Thrimawithana
Dr. Ayman Allahham
Guest Editors
Manuscript Submission Information
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Keywords
- drug stability
- oral drug delivery
- in vitro assessment
- dissolution
- oral medication lubricants
- nano-formulations
- biologics
- stability enhancement
- real-time stability assessment
- drug release kinetics
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