Smart Responsive Nanocomposite as Advanced Drug Delivery System in Regenerative Tissue Engineering

Dear Colleagues,

We are pleased to invite contributions to this Special Issue, entitled “Smart Responsive Nanocomposite as Advanced Drug Delivery System in Regenerative Tissue Engineering”. The integration of nanotechnology with tissue engineering has opened up new therapeutic advancements, particularly in the controlled and targeted delivery of bioactive molecules. Smart responsive nanocomposites, which combine nanomaterials with stimuli-responsive polymers, are emerging as a promising platform for drug delivery systems (DDSs) that can be precisely controlled by external or internal stimuli such as pH, temperature, or light. These advanced nanocomposites enable dynamic interactions with the cellular microenvironment, enhancing tissue regeneration and healing processes.

The application of these nanomaterials in regenerative medicine holds immense potential for improving the efficacy of drug delivery, particularly in the repair and regeneration of damaged tissues and organs. By providing localized and sustained release growth factors, cytokines, or other bioactive agents, smart responsive nanocomposites can significantly improve patient outcomes in conditions such as wound healing, bone regeneration, and cartilage repair. This research area is critical for advancing the development of next-generation therapeutic strategies in tissue engineering, offering novel solutions for personalized medicine and precision therapy.

This Special Issue, entitled “Smart Responsive Nanocomposite as Advanced Drug Delivery System in Regenerative Tissue Engineering”, aims to explore the latest advancements in the development and application of nanocomposite materials that respond to external or internal stimuli for targeted, controlled, and sustained drug delivery in tissue regeneration. We aim to highlight innovative research on the design, fabrication, and functionalization of smart nanocomposites, as well as their integration with regenerative therapies for bone, cartilage, neural, and cardiac tissues. This Special Issue also aims to address challenges in biocompatibility, safety, and scalability, and explore the potential for clinical translation.

In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following:

• Stimuli-responsive nanocomposites for drug delivery;
• Stimuli-responsive nanocomposites based on biopolymers; 
• Targeted and controlled drug delivery;
• Stimuli-responsive mechanisms in targeted drug delivery;
• Stimuli-responsive nanocomposites in regenerative medicine;
• Biological safety of stimuli-responsive nanocomposites in tissue engineering applications;
• Exosome-loaded stimuli-responsive nanocomposites for enhanced tissue regeneration;
• Stimuli-responsive nanocomposites for neuronal disorders;
• Multifunctional nanocomposites for advanced drug delivery;
• Nanocomposite-based systems for bone tissue regeneration;
• Smart nanocomposites for drug delivery in cartilage regeneration;
• Nanocomposites with RNA delivery in regenerative medicine;
• Stimuli-responsive nanocomposite-based platforms for cardiac tissue engineering;
• Graphene-based nanocomposites for smart drug delivery in tissue engineering;
• Nanocomposite-based platforms for gene therapy in tissue engineering;
• Self-healing and biodegradable nanocomposites for controlled drug delivery;
• Redox-responsive nanocomposites for antioxidant therapeutics;
• Toxicity and biodegradability of stimuli-responsive nanocomposites.

We look forward to receiving your contributions.

Dr. Mantosh Kumar Satapathy
Dr. Tao L. Lowe
Guest Editors

Manuscript Submission Information

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• advanced drug delivery
• stimuli-responsive nanocomposite
• regenerative medicine
• biomaterials
• gene therapy