Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.4
1.4
Journals
Pediatric Reports
Sections
Recent Advances and Critical Issues in Pediatrics: a Collection of...
share announcement

Recent Advances and Critical Issues in Pediatrics: a Collection of Feature Papers

A topical collection in Pediatric Reports (ISSN 2036-7503).

Viewed by 6773

Editors

Dr. Maurizio Aricò

E-Mail Website
Collection Editor
Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy
Interests: antineoplastic combined chemotherapy protocols; precursor cell lymphoblastic leukemia–lymphoma; DNA mutational analysis; Down syndrome; survival analysis; combined modality therapy; histiocytosis; Langerhans cell; cellular cytotoxicity; acute lymphoblastic leukemia; rare diseases; hospital management
Special Issues, Collections and Topics in MDPI journals
Dr. Claudia Mandato

E-Mail Website
Collection Editor
Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, SA, Italy
Interests: pediatrics; hepatology; nutrition
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pietro Vajro

E-Mail Website
Collection Editor
Former Director Pediatrics Section, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, SA, Italy
Interests: liver; gastroenterology; obesity; children; interplay GI/nutrition and liver disease
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Pediatric subspecialties play an essential role in improving children’s health outcomes by providing very specific care. Over the last several years, there has been unprecedented progress reported in all subspecialities due to a better understanding of disease pathomechanisms and the availability of new diagnostic and preventive/therapeutic solutions.

Considering this, the purpose of this Special Issue devoted to feature papers is to gather key information on the state-of-the-art insights that have opened up innovative avenues for the medical management of infants, children, and adolescents in all pediatric subspecialties. Overall, this Special Issue provides an excellent opportunity to explore the latest research and practice directions and, at the same time, focus on previously unaddressed critical issues.

Scholars in a variety of disciplines that fall under the scope of this Special Issue are encouraged to submit high-quality papers that showcase the most recent advancements within their own field of study regarding prevention, diagnosis, and treatment in acute and chronic pediatric diseases. This Special Issue will therefore represent a useful resource for clinicians and scientists, providing them with the most pertinent new information.

We also welcome both narrative and systematic reviews on topics within the field of pediatric subspecialties. Areas of study may include, but are not limited to, the following: allergies and immunology; cardiology; endocrinology; gastroenterology/hepatology/nutrition; hematology/oncology; infectious diseases; inherited metabolic diseases; neonatology; nephrology; neurology; obesity; pulmonology; rheumatology; and the transition from the pediatric to adult healthcare system.

We look forward to receiving your contributions.

Dr. Claudia Mandato
Dr. Maurizio Aricò
Prof. Dr. Pietro Vajro
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pediatric Reports is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric subspecialties
  • pediatric patients management
  • diagnostic and preventive/therapeutic solutions

Published Papers (5 papers)

Download All Papers

2026

Jump to: 2025

12 pages, 450 KB  
Review
Acquired Platelet Dysfunction with Eosinophilia: A Narrative Review
by Anselm Chi-Wai Lee
Pediatr. Rep. 2026, 18(3), 66; https://doi.org/10.3390/pediatric18030066 - 7 May 2026
Viewed by 241
Abstract
Background. Acquired platelet dysfunction with eosinophilia (APDE) is a transient bleeding disorder initially thought to occur exclusively in Southeast Asia. There are no uniformly agreed diagnostic criteria, and its full clinical features have not been defined. Methods. A literature search was [...] Read more.
Background. Acquired platelet dysfunction with eosinophilia (APDE) is a transient bleeding disorder initially thought to occur exclusively in Southeast Asia. There are no uniformly agreed diagnostic criteria, and its full clinical features have not been defined. Methods. A literature search was conducted through MEDLINE, EMBASE, and Google Scholar for publications on APDE in order to explore patient demography, epidemiology, diagnostic criteria, and laboratory findings of the disease. Results. Ten retrospective, observational studies, five case series, and 21 case reports were identified with a total of 431 patients. Diagnostic criteria varied, with a two-tier approach for the diagnosis of impaired platelet function. In recent years, cases of APDE have been reported extensively outside of the Malay peninsula. Male patients (243/390, 62.3%) predominated. Their ages ranged from 11 months to 30 years, with only 40 (9.3%) subjects aged 18 years or older. Eosinophilia was absent in 10 to 33% of subjects in a few observational studies. Thrombocytopenia was present in 42 (9.7%) subjects. Parasitic infestation was less common in the new millennium. Spontaneous recovery within six months was the trend, and serious complications were extremely rare. Conclusions. APDE is no longer restricted to Southeast Asia. A uniform set of diagnostic criteria is needed. Clinician awareness followed by reliable but easily available laboratory tests is essential to confirm diagnosis. It is proposed that rapid diagnosis can be accomplished by screening the blood smear for grey platelets by a trained examiner followed by confirmatory platelet aggregometry. National or international collaboration and prospective studies are required to delineate the core and variable clinical and laboratory features of APDE. Full article
►▼ Show Figures

Figure 1

9 pages, 1491 KB  
Brief Report
Point-of-Care Ultrasound Detects Rapid Muscle Loss in Pediatric ECMO Patients—A Secondary Analysis Paper
by Mohammad Sabobeh, Elizabeth Seewer, William Hunt Stafford, Nicolas Chiriboga, Thomas Spentzas, Shyam Popat, Alyssa Clark, David B. Kantor, Hitesh S. Sandhu and Saad Ghafoor
Pediatr. Rep. 2026, 18(3), 63; https://doi.org/10.3390/pediatric18030063 - 1 May 2026
Viewed by 205
Abstract
Background: Critically ill children requiring extracorporeal membrane oxygenation (ECMO) support are at high risk of immobility, deconditioning, and muscle loss. There is a lack of screening and diagnostic tools to quantify muscle loss in this population. Objective: This study aims to evaluate the [...] Read more.
Background: Critically ill children requiring extracorporeal membrane oxygenation (ECMO) support are at high risk of immobility, deconditioning, and muscle loss. There is a lack of screening and diagnostic tools to quantify muscle loss in this population. Objective: This study aims to evaluate the use of bedside ultrasound as a practical and effective method for detecting muscle loss in this high-risk group. Materials and Methods: This is a secondary analysis of a prospective observational clinical study conducted between January 2024 and January 2025 that used ultrasound to describe muscle loss in critically ill children aged 2 to 18 years. Results: The primary study enrolled 35 patients, five of whom required ECMO support. All patients who required ECMO showed significant muscle loss (>10%) in the quadriceps femoris, as measured by muscle thickness and cross-sectional area, compared with baseline measurements obtained before ECMO cannulation. Conclusions: Point-of-care muscle ultrasound could be a reliable, cost-effective tool for assessing muscle loss in pediatric patients on ECMO. Full article
►▼ Show Figures

Figure 1

2025

Jump to: 2026

6 pages, 642 KB  
Case Report
Successful Treatment of Multilevel Tracheal Stenosis Post Blunt Chest Trauma in a Child by Early Bronchoscopic Balloon Dilatation: A Case Report
by Badar Al Dhouyani, Atqah AbdulWahab, Muna Maarafiya, Bilal Kabbara and Mutasim Abu-Hasan
Pediatr. Rep. 2025, 17(6), 117; https://doi.org/10.3390/pediatric17060117 - 4 Nov 2025
Viewed by 927
Abstract
Background: Tracheal stenosis in children is a rare but potentially life-threatening condition. We report a case of multilevel tracheal stenosis in a child who sustained blunt chest trauma in a car accident. Case Presentation: The patient is an 11-year-old previously healthy boy who [...] Read more.
Background: Tracheal stenosis in children is a rare but potentially life-threatening condition. We report a case of multilevel tracheal stenosis in a child who sustained blunt chest trauma in a car accident. Case Presentation: The patient is an 11-year-old previously healthy boy who presented to the pediatric emergency room unconscious after being rolled over while seated unstrained inside a vehicle. A chest CT scan showed bilateral pulmonary contusions. He required intubation and mechanical ventilation initially but was noted to have biphasic stridor after extubation. He presented to the pediatric pulmonary clinic 2 weeks after discharge from the hospital with persistent stridor and shortness of breath on exertion. Spirometry revealed flattening of the inspiratory and expiratory limbs of the flow-volume loop, suggestive of fixed large airway obstruction. Direct laryngoscopy and bronchoscopy were performed and revealed multilevel tracheal stenosis. He was successfully treated with repeated bronchoscopic balloon dilatation with sustained improvement in symptoms and spirometry findings 8 months post final procedure. Conclusion: Tracheal stenosis should be suspected in children who sustain blunt chest trauma. Early recognition and treatment with bronchoscopic balloon dilatation can prevent long-term complications. Full article
►▼ Show Figures

Figure 1

13 pages, 882 KB  
Article
Descriptive Analysis of Pediatric Studies Included in the European Union Post-Authorization Study Register from 2010 to 2023
by Annalisa Landi, Giorgio Reggiardo, Antonella Didio, Annunziata D’Ercole, Adriana Ceci, Grace Shalom Govere, Donato Bonifazi, Fedele Bonifazi, Salvatore Crisafulli, Gianluca Trifirò, Florentia Kaguelidou, Katja Marja Hakkarainen, Katarina Gvozdanović, Francesco Barone-Adesi, Andrealuna Ucciero and Mariagrazia Felisi
Pediatr. Rep. 2025, 17(1), 24; https://doi.org/10.3390/pediatric17010024 - 16 Feb 2025
Viewed by 1579
Abstract
Background/Objectives: This work aimed to analyze pediatric Post-Authorization Studies (PASs) registered in the European Union electronic Register of Post-Authorization Studies (EU PAS Register) from September 2010 to April 2023 to identify trends in terms of timing, age groups, and therapeutic areas and to [...] Read more.
Background/Objectives: This work aimed to analyze pediatric Post-Authorization Studies (PASs) registered in the European Union electronic Register of Post-Authorization Studies (EU PAS Register) from September 2010 to April 2023 to identify trends in terms of timing, age groups, and therapeutic areas and to discuss pediatric specificities and sources of funding for the PASs. Methods: A screening process identified PASs conducted exclusively on the pediatric population, and instructions were provided to ensure standardized data collection from the EU PAS Register. A univariate linear regression descriptive analysis was performed to assess trends over time, while a multivariate linear regression analysis helped explore additional characteristics of these studies. Results: Of the 2574 PASs extracted from the EU PAS Registry, 165 were included in this analysis. The majority of pediatric PASs were observational studies (86%), and most of them utilized secondary data (53%). The annual number of PASs increased significantly between 2010 and 2023. As envisaged, the largest part was funded by pharmaceutical companies (62%). Anti-infectives for systemic uses (25%), medicines for the nervous system (18%), and antineoplastic and immunomodulating agents (15%) resulted in the most studied drugs. Conclusions: Our findings show that post-marketing observational research in pediatric populations has increased over time. Nevertheless, industry–academia collaboration should be encouraged, and regulatory guidance is needed to prioritize research in areas of unmet therapeutic need. Full article
►▼ Show Figures

Figure 1

7 pages, 559 KB  
Communication
Should the Definition of Low Birth Weight Be Same in Every Ethnicity Considering the DOHaD Concept?
by Yoshifumi Kasuga and Mamoru Tanaka
Pediatr. Rep. 2025, 17(1), 8; https://doi.org/10.3390/pediatric17010008 - 16 Jan 2025
Viewed by 2017
Abstract
Low birth weight (LBW) is a significant concern not only because of its association with perinatal outcomes, but also because of its long-term impact on future health. Despite the physical differences among individuals of different ethnicities, the definition of LBW remains the same [...] Read more.
Low birth weight (LBW) is a significant concern not only because of its association with perinatal outcomes, but also because of its long-term impact on future health. Despite the physical differences among individuals of different ethnicities, the definition of LBW remains the same for all ethnicities. This study aimed to explore and discuss this issue. We compiled national data from several countries and found that maternal height was negatively correlated with LBW incidence. We discovered the INTERGROWTH-21st chart may not be suitable for the Japanese population, as the Japanese birth weight chart differs from the INTERGROWTH-21st chart. Researchers have reported different LBW cutoff values used to assess adverse perinatal outcomes for different countries. However, there is currently no definition of LBW independent of the mother’s country of origin that can be used for predicting the risk of adverse health outcomes. Therefore, the current era of personalized healthcare may be the perfect time to establish a standard definition of LBW which is independent of the mother’s country of origin. Considering the future of healthcare, it seems an apt time to discuss the development of a more meaningful definition of LBW that can be applied across ethnicities. Further research is needed to investigate the cutoff values of LBW in every ethnicity. Full article
►▼ Show Figures

Figure 1

Back to TopTop