Biomedical Engineering Applied to Pathophysiological Processes

A special issue of Pathophysiology (ISSN 1873-149X).

Deadline for manuscript submissions: 1 May 2025 | Viewed by 1657

Special Issue Editors


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Guest Editor
LSU Health Sciences Center-Shreveport, Shreveport, LA, USA
Interests: biomechanics; hip; hand; spine; bone; gait; imaging
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Guest Editor
Department of Textiles, Merchandising and Interiors, University of Georgia, Athens, GA, USA
Interests: fibers; scaffolds; medical textiles; antimicrobials

Special Issue Information

Dear Colleagues,

We are delighted to invite you to contribute to a Special Issue for Pathophysiology, which will be selected from presentations at the 40th SBEC on Biomedical Engineering, taking place in Shreveport, 13–15 September 2024 (https://sbeconference.org/40th-sbec/).

For this Special Issue of Pathophysiology, we will gather a comprehensive collection of studies applying principles and techniques from the field of biomedical engineering to comprehend, analyze, and intervene in the processes associated with diseases or abnormal physiological conditions in the human body. We invite manuscripts that center on the development of diagnostic tools and therapeutic interventions, as well as the modelling and simulation of pathophysiological mechanisms.

Dr. Giovanni F. Solitro
Dr. Vladimir Reukov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathophysiology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • physiology
  • chronic
  • congenital
  • etiology
  • diagnosis
  • simulations
  • therapeutics

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Published Papers (1 paper)

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Research

13 pages, 6166 KiB  
Article
Evaluation of Full Thickness Wounds Following Application of a Visco-Liquid Hemostat in a Swine Model
by Michelle Tucci, Drew Hildebrandt, Joseph Lichtenhan and Hamed Benghuzzi
Pathophysiology 2024, 31(3), 458-470; https://doi.org/10.3390/pathophysiology31030034 - 29 Aug 2024
Cited by 1 | Viewed by 953
Abstract
Wound healing is a complex dynamic biomechanical process as the body attempts to restore the integrity of traumatized or devitalized tissues. There are four stages of wound of healing that begins with hemostasis followed by inflammation, proliferation and finally weeks later wound remodeling. [...] Read more.
Wound healing is a complex dynamic biomechanical process as the body attempts to restore the integrity of traumatized or devitalized tissues. There are four stages of wound of healing that begins with hemostasis followed by inflammation, proliferation and finally weeks later wound remodeling. Full thickness wounds usually are covered with a dressing material after hemostasis, which allows for controlled hydration. We investigated the potential of a visco-liquid hemostat, polyhedral oligomeric silsesquioxane (POSS), for providing hemostasis and to maintain a microenvironment in the wound bed that would maintain moisture content and promote early re-epithelialization. We hypothesized that the hemostatic agent POSS if left in the wound bed would maintain a protective barrier and accelerate wound healing similar to using saline to irrigate the wound to keep the wound moist. We compared the early phase of wound repair (3–7 days) in a porcine full thickness wound model to evaluate the efficacy of the material. Biopsies were taken after 3 and 7 days to determine the acute response of the POSS hemostat or saline on inflammation, cell migration, concentrations of metalloproteinase (MMPs), and tissue inhibitors of metalloproteinase (TIMPs). Accelerated healing was observed in POSS treated wounds by changes in wound contraction, keratinocyte migration, and development of granulation tissue in comparison to saline treated wounds. Increased concentrations at day 3 of MMP-2, MMP-3, and in MMP-1 at day 7 in POSS treated wounds compared to saline coincide with keratinocyte migration observed in the tissue histology and changes in wound contraction. Tissue concentrations of TIMP-1 and TIMP-2 in POSS treated wounds appear to coordinate the sequence of MMP events in the healing tissue. Matrix metalloproteinase-13, a marker for tissue remodeling, was not upregulated in the early wound healing cascade in either POSS or saline treated wounds at 3 or 7 days. Overall, the data suggests POSS treatment contributed to enhanced early cell migration and wound closure compared to saline treatment. Full article
(This article belongs to the Special Issue Biomedical Engineering Applied to Pathophysiological Processes)
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