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Pathogens
Special Issues
Malaria: Updates on Prevention, Diagnosis, and Treatment
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Malaria: Updates on Prevention, Diagnosis, and Treatment

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 4083

Special Issue Editors

Dr. Temi Lampejo

E-Mail Website
Guest Editor
King's College Hospital, London, UK
Interests: infectious diseases; tropical diseases; viruses; pyrexia of unknown origin
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrew Taylor-Robinson

E-Mail Website1 Website2 Website3
Guest Editor
1. College of Health Sciences, VinUniversity, Gia Lam District, Hanoi 67000, Vietnam
2. Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: vector-borne infectious diseases; neglected tropical diseases; emerging infectious diseases; malaria; dengue; arboviruses; epidemiology; immunology; diagnostics; vaccine development

Special Issue Information

Dear Colleagues,

Malaria continues to have a devastating global health burden, being responsible for 263 million cases and 597,000 deaths in 2023, across 83 countries. This is likely to continue for the foreseeable future unless further preventative strategies are implemented. Progress is being made: the forwarding by the World Health Organisation (WHO) in October 2021 of the first vaccine against Plasmodium falciparum malaria as well as developments in monoclonal antibodies for malaria prevention show this. However, therapeutic strategies are being threatened by the emergence of partial artemisinin resistance in certain parts of the world including South America, East Africa, and Southeast Asia.

The aim of this Special Issue is to explore and further expand our understanding of the evolving epidemiology and immunopathogenesis of malaria (all species), as well as to report on novel developments in its prevention, diagnosis, and treatment. A range of studies, including case reports and series, cohort and case–control studies, narrative reviews, and systematic reviews and meta-analyses, are welcome.

Dr. Temi Lampejo
Prof. Dr. Andrew Taylor-Robinson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malaria
  • plasmodium
  • prevention
  • vaccines
  • therapeutics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

22 pages, 313 KB  
Review
Are pfhrp2 and pfhrp3 Deletions a Concern in Latin America? A Critical Review
by Beatriz Pires da Silva, Pablo Secato Fontoura, Cláudio Tadeu Daniel-Ribeiro and Maria de Fátima Ferreira-da-Cruz
Pathogens 2026, 15(4), 368; https://doi.org/10.3390/pathogens15040368 - 31 Mar 2026
Viewed by 658
Abstract
Plasmodium falciparum with deletions in the pfhrp2 and pfhrp3 genes has increasingly challenged national malaria control efforts worldwide by reducing the reliability of HRP2-based rapid diagnostic tests. This review explores available reports and evidence on this issue across Latin America. The results show [...] Read more.
Plasmodium falciparum with deletions in the pfhrp2 and pfhrp3 genes has increasingly challenged national malaria control efforts worldwide by reducing the reliability of HRP2-based rapid diagnostic tests. This review explores available reports and evidence on this issue across Latin America. The results show a varied distribution, with countries such as Peru, Colombia, and Brazil reporting the emergence and spread of multidrug-resistant strains. Meanwhile, Caribbean countries and parts of Central America report low prevalence or no deletions. Understanding these patterns is essential for adjusting surveillance strategies, especially in countries nearing malaria elimination. Full article
(This article belongs to the Special Issue Malaria: Updates on Prevention, Diagnosis, and Treatment)
26 pages, 674 KB  
Review
The Evolving Landscape of Malaria Prevention Strategies: A Review of Recent Developments
by Yathavi Charavanamuttu, Akosua Agyeman Wamba, Andrew W. Taylor-Robinson and Temi Lampejo
Pathogens 2026, 15(2), 137; https://doi.org/10.3390/pathogens15020137 - 26 Jan 2026
Cited by 1 | Viewed by 2490
Abstract
Malaria continues to impose a devastating disease burden globally despite control efforts spanning decades. Its elimination has been hindered by parasite and vector complexity and emerging drug and insecticide resistance, along with unremitting barriers to uptake of preventative strategies largely driven by social [...] Read more.
Malaria continues to impose a devastating disease burden globally despite control efforts spanning decades. Its elimination has been hindered by parasite and vector complexity and emerging drug and insecticide resistance, along with unremitting barriers to uptake of preventative strategies largely driven by social inequities, cost constraints, and logistical challenges in implementation. This review synthesises current and emerging prevention strategies, including vector control, chemoprevention and immunoprophylaxis. Insecticide-treated nets and indoor residual spraying remain cornerstones of vector control, although their effectiveness is increasingly compromised by widespread insecticide resistance. Chemoprevention, including intermittent preventive treatment in pregnancy and seasonal malaria chemoprevention in children, has proven highly efficacious, yet uptake remains below WHO targets and concerns about drug resistance remain. Recent advances in vaccines, notably RTS,S/AS01 and R21/Matrix-M, represent landmark achievements, with large-scale rollouts demonstrating reductions in severe disease and mortality. Novel approaches, such as monoclonal antibodies and genetically modified mosquitoes, offer promising avenues for future prevention. However, challenges remain in ensuring equitable access, sustaining efficacy in the face of evolving parasite and vector biology, and integrating interventions into diverse health systems. This review highlights the need for adaptive, multifaceted approaches to achieve malaria elimination goals. Full article
(This article belongs to the Special Issue Malaria: Updates on Prevention, Diagnosis, and Treatment)
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