Therapeutic Strategies for Mycobacterium Infections Novel Drug Development
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 5
Special Issue Editors
Interests: immunology; mycrobiology; Mycobacterium tuberculosis infection
Interests: antimicrobial peptide; atopic dermatitis; barrier function; epidermal barrier; filaggrin; skin barrier repair; dry skin; intractable itch; itch/pruritus; keratinocyte; sensory nerve fiber
Special Issue Information
Dear Colleagues,
Tuberculosis (TB), particularly in its multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms, remains a critical global public health concern. The limited efficacy of conventional treatments, along with the alarming rise in antimicrobial resistance, underscores the urgent need for novel therapeutic strategies. Mycobacterium tuberculosis (MTB) possesses a uniquely complex cell wall structure, rich in lipids, along with adaptive mechanisms that hinder antibiotic penetration and efficacy. These features complicate treatment and contribute to the persistence of infection.
In response to these challenges, the development of new therapeutic agents has become a global health priority. Innovative tools based on rational drug design, combined with advances in structural biology, functional genomics, artificial intelligence, and nanotechnology, open promising avenues for accelerating the discovery of effective treatments against resistant and latent Mycobacterium strains.
In this context, we invite the scientific community to contribute original research articles, systematic reviews, and short communications focused on therapeutic strategies for mycobacterial infections, particularly those involving novel drug development. Contributions may address, but are not limited to, the following topics:
- Rational drug design targeting Mycobacterium tuberculosis;
- Development and validation of antimycobacterial compounds;
- Artificial intelligence and machine learning in antimicrobial activity prediction;
- Studies on pharmacological synergy and combination therapies;
- Mechanisms of drug resistance and strategies to overcome them;
- Immunomodulatory approaches and therapeutic vaccines.
Dr. Adrían Rodríguez-Carlos
Dr. Juan Valentin Trujillo-Paez
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Mycobacterium infections
- drug development
- tuberculosis treatment
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