Innate and Adaptive Immune Responses to Tuberculosis and Nontuberculous Mycobacterial Infections
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 308
Special Issue Editor
2. Department of Microbial Immunity and Infection, The Ohio State University, Columbus, OH 43210, USA
3. Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA
Interests: Mycobacterium tuberculosis; nontuberculous mycobacterial infections; immune evasion
Special Issue Information
Dear Colleagues,
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is responsible for more than a million death per year. Nontuberculous mycobacteria can affect many body sites. The prevalence of nontuberculous mycobacteria (NTM) diseases are also increasing worldwide. Innate and adaptive immune responses play a crucial role in the pathogenesis and control of TB and non-TB infections. However, most of the classical studies focus on T cell responses. Recent advancements of novel immunological techniques such as single-cell RNA sequencing and high dimensional flow cytometry expanded the knowledge of diverse innate and adaptive immune cell responses and their multiple cellular interactions during TB and NTB infections.
Our Research Topic highlights recent advances in Mycobacterium-induced innate and adaptive immune responses. Understanding the mechanisms of mycobacterial -host immune cell interactions will contribute to developing novel treatment and preventive vaccines against mycobacterial infections.
We welcome submissions of original research and review articles covering on the following areas:
- Host innate and adaptive immune responses and mechanisms to control M. tuberculosis and non-tuberculous mycobacteria infections.
- Mycobacterial strategies and mechanisms used to escape or evade host defense system
- Activation of Innate signaling pathways to mycobacteria
- Epigenetics modification in the immune cells to MtB or non-MTB infection.
- Innate and adaptive Immune responses to BCG
- Epigenetics modification to the BCG vaccination
Dr. Namal P. M. Liyanage
Guest Editor
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Keywords
- Mycobacterium tuberculosis
- nontuberculous mycobacterial Infections
- T cell responses
- NK cell responses
- monocytes
- B cells
- cellular targets
- immune evasion
- mycobacteria-host immune cell interactions
- epigenetic regulation to BCG
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