Pathogens in Dentistry: Diversity, Virulence, Resistance, and Control
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: 15 January 2026 | Viewed by 91
Special Issue Editor
Special Issue Information
Dear Colleagues,
The oral cavity harbors a complex and diverse microbiota, including a wide range of pathogenic microorganisms that play critical roles in dental diseases. Pathogens in dentistry are not only responsible for common conditions such as dental caries and periodontitis but are also implicated in systemic infections through oral–systemic connections. The diversity of these pathogens, encompassing bacteria, fungi, and viruses, challenges traditional diagnostic and treatment approaches.
Virulence factors in oral pathogens, such as biofilm formation, enzyme production, and immune evasion mechanisms, contribute to their persistence and destructive potential. Biofilms, in particular, protect microbes from environmental stresses and antimicrobial agents, complicating infection control. The rise in antimicrobial resistance (AMR) among dental pathogens further exacerbates treatment difficulties, necessitating innovative strategies to overcome resistant strains.
Current control measures involve the mechanical removal of biofilms, the use of antiseptics, and systemic or local antibiotics. However, increasing resistance and the complex ecology of the oral microbiome demand more targeted and sustainable approaches. Advances in molecular diagnostics, microbial genomics, and host immune modulation offer promising avenues for personalized dental care and effective pathogen control.
This Special Issue will explore the latest research on diversity, virulence mechanisms, resistance patterns, and novel control strategies in dental pathogens. A multidisciplinary understanding is essential in improving the prevention and management of oral infections, ultimately enhancing overall health outcomes.
Dr. Gláuber Campos Vale
Guest Editor
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Keywords
- oral pathogens
- biofilm
- dental caries
- periodontitis
- virulence factors
- antimicrobial resistance
- microbiome
- infection control
- molecular diagnostics
- host immunity
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