Molecular Mechanisms and Clinical Management of HIV–Hepatitis Virus Coinfections
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".
Deadline for manuscript submissions: 15 September 2026
Special Issue Editors
2.“Prof. Dr. Matei Balş” National Institute of Infectious Diseases, 021105 Bucharest, Romania
Interests: HIV; epidemiology; infectious diseases
Interests: HPV; HIV; viral hepatitis; virus molecular evolution; host–pathogen interaction; zoonoses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to gather original research articles, reviews, and clinical studies exploring the molecular aspects and medical care of HIV coinfection with hepatitis viruses B (HBV), D (HDV), and C (HCV). It encompasses exploration into molecular mechanisms driving liver disease, immune system interplay, viral replication dynamics, and disease progression in coinfected patients. Studies on biomarkers, antiviral treatment outcomes, virological monitoring, and novel therapeutic targets for managing HIV–hepatitis coinfections are also welcome. The issue seeks to bridge molecular insights with clinical management strategies to improve patient outcomes in this challenging comorbidity.
Coinfection with human immunodeficiency virus (HIV) and hepatitis viruses, particularly HBV and HCV, represents a significant global health challenge, due to the high risk of liver disease progression and difficulties in clinical management. Molecular interplay between HIV and hepatitis viruses exacerbates liver injury through diverse mechanisms, including direct modulation of viral replication, immune dysregulation, and enhanced hepatocyte apoptosis. Understanding these molecular pathways is essential to identifying biomarkers for disease staging and to developing targeted treatments. Concurrently, clinical management faces unique obstacles such as antiviral drug interactions, treatment adherence, and monitoring challenges, which impact therapeutic success and patient prognosis. This Special Issue invites comprehensive studies that illuminate the virological and immunological mechanisms underlying HIV–hepatitis coinfections and translate these findings into clinical approaches. By integrating basic molecular research with clinical data, the collection aims to advance knowledge on effective management strategies and pave the way for improved outcomes in coinfected populations worldwide.
Dr. Ana Maria Tudor
Dr. Anna Rosa Garbuglia
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- HIV-Hepatitis coinfection
- liver disease progression
- antiviral therapy
- clinical management
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