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Organics
Special Issues
Design and Development of New Organic Synthetic Methods and Techniques
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Design and Development of New Organic Synthetic Methods and Techniques

A special issue of Organics (ISSN 2673-401X).

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 10246

Special Issue Editors

Dr. Ting Wang

E-Mail Website
Guest Editor
Department of Chemistry, State University of New York at Albany, Albany, NY 12222, USA
Interests: new synthetic methods for natural product synthesis; ew synthetic strategies; photocatalysis; catalysis; organocatalysis; photoredox catalysis; electrocatalysis; organic synthesis
Dr. Li Xiao

E-Mail Website
Guest Editor
ASO Process Development and Manufacturing Biogen, Cambridge, MA 02142, USA
Interests: the process development of active pharmaceutical ingredients; small molecule; oligonucleotide and peptides

Special Issue Information

Dear Colleagues,

The continuous development of new organic synthetic methods and techniques is of great importance in medicinal chemistry and drug discovery, material sciences, agriculture sciences, etc. As a result, tremendous efforts have been made regarding both novel synthetic method development and new synthetic technique exploration. In the past several decades, a great number of novel synthetic areas have been explored, such as organocatalysis, photoredox catalysis, and electrocatalysis. Meanwhile, new synthetic techniques and instruments have also been developed, such as flow chemistry and flow reactors, microwave-assisted reactions and associated reactors, photoreactions and photoreactors, and electroreactions and electroreactors. Some of these new synthetic methods and techniques have already been utilized in industrial settings. This Special Issue aims to publish the latest research results dedicated to all aspects of new discoveries of organic synthetic methods and techniques, including, but not limited to, the discovery of new chemical transformations, catalyst development, technique development, etc.

Dr. Ting Wang
Dr. Li Xiao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic method development
  • new synthetic technique
  • catalysis
  • organocatalysis
  • photocatalysis
  • electrocatalysis
  • flow chemistry
  • microwave-assisted reaction
  • reactor

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Published Papers (3 papers)

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Research

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8 pages, 1600 KiB  
Communication
Palladium Catalyzed Allylic C-H Oxidation Enabled by Bicyclic Sulfoxide Ligands
by Yuming Wen, Jianfeng Zheng, Alex H. Evans and Qiang Zhang
Organics 2023, 4(2), 289-296; https://doi.org/10.3390/org4020023 - 13 Jun 2023
Cited by 1 | Viewed by 1975
Abstract
The activation of C-H bonds is a potent tool for modifying molecular structures in chemistry. This article details the steps involved in a novel ligand bearing a bicyclic [3.3.1]-nonane framework and bissulfoxide moiety. A palladium catalyzed allylic C-H oxidation method enables a direct [...] Read more.
The activation of C-H bonds is a potent tool for modifying molecular structures in chemistry. This article details the steps involved in a novel ligand bearing a bicyclic [3.3.1]-nonane framework and bissulfoxide moiety. A palladium catalyzed allylic C-H oxidation method enables a direct benzyl-allylic functionalization with the bissulfoxide ligand. Bissulfoixde ligand possesses a rapidly constructed bicyclic [3.3.1] framework and it proved to be effective for enabling both N- and C-alkylation. A total of 13 C-H activation productions were reported with good to excellent yields. This report validated that it is necessary to include bissulfoxide as a ligand for superior reactivities. Naftifine was produced utilizing developed C-H functionalization methodology in good overall yields. Full article
(This article belongs to the Special Issue Design and Development of New Organic Synthetic Methods and Techniques)
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10 pages, 3342 KiB  
Communication
A Reaction of N-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids
by Bogdan A. Tretyakov, Svyatoslav Y. Gadomsky and Alexei A. Terentiev
Organics 2023, 4(2), 186-195; https://doi.org/10.3390/org4020015 - 27 Apr 2023
Cited by 1 | Viewed by 3774
Abstract
We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is the synthesis of N-substituted succinimide [...] Read more.
We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is the synthesis of N-substituted succinimide via the reaction of aromatic amine or carboxylic acid hydrazide with succinic anhydride. The second step involves the imide ring opening reaction by hydroxylamine. For both stages, universal synthetic methods are developed to exclude additional purification procedures for the target compounds. Sixteen hydroxamic acids are synthesized using the developed approach. Most of the compounds are obtained for the first time. Full article
(This article belongs to the Special Issue Design and Development of New Organic Synthetic Methods and Techniques)
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Review

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31 pages, 13206 KiB  
Review
Recent Advances in Application of Alkoxy Radical in Organic Synthesis
by Munsaf Ali, Shi Sewell, Juncheng Li and Ting Wang
Organics 2023, 4(4), 459-489; https://doi.org/10.3390/org4040033 - 28 Sep 2023
Cited by 1 | Viewed by 3695
Abstract
Alkoxy radicals have been identified as versatile intermediates in synthetic chemistry in the last few decades. Over the last decade, various catalytic processes for the in situ generation of alkoxy radicals have been explored, leading to the development of new synthetic methodologies based [...] Read more.
Alkoxy radicals have been identified as versatile intermediates in synthetic chemistry in the last few decades. Over the last decade, various catalytic processes for the in situ generation of alkoxy radicals have been explored, leading to the development of new synthetic methodologies based on alkoxy radicals. In this review, we provided a comprehensive review of recent developments in the utilization of alkoxy radicals in diverse organic transformations, natural product synthesis, and the late-stage modification of bioactive molecules through the implementation of the photoredox methodology. Full article
(This article belongs to the Special Issue Design and Development of New Organic Synthetic Methods and Techniques)
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