Protein Interactions in Neurological Disorders
A special issue of Neurology International (ISSN 2035-8377).
Deadline for manuscript submissions: 31 January 2026 | Viewed by 28
Special Issue Editors
Interests: neurology; neuroscience; Alzheimer’s disease; Parkinson’s disease
Special Issue Information
Dear Colleagues,
Abnormal protein–protein interactions are a hallmark of many neurological disorders, contributing to synaptic dysfunction, neuroinflammation, and progressive neuronal damage. Misfolded or aggregated proteins such as amyloid-β, tau, α-synuclein, and TDP-43 can disrupt cellular homeostasis and trigger inflammatory cascades that exacerbate disease progression. These interactions are particularly detrimental at the synapse, where they impair plasticity and signaling and ultimately lead to cognitive and functional deficits.
This Special Issue aims to explore how pathological protein interactions contribute to the onset and progression of neurological disorders, with a specific emphasis on their role in driving neuroinflammation and synaptic alterations. We welcome original research articles and reviews that investigate the molecular and cellular mechanisms underlying these processes in conditions such as Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, and other neurodegenerative or neuroinflammatory diseases. Studies involving key proteins, including, but not limited to, amyloid-β, tau, and the cellular prion protein, are encouraged.
Submissions may include mechanistic studies, protein interaction mapping, inflammation signaling analysis, synaptic physiology, biomarker identification, or therapeutic interventions targeting protein networks. This collection seeks to provide a comprehensive overview of how disrupted protein crosstalk and inflammatory signaling converge at the synapse to drive pathology in the brain.
Dr. Li Fu
Dr. Qinfang Liu
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- molecular signaling pathways
- neurodegeneration
- synaptic dysfunction
- misfolded proteins
- neuroinflammation
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