Acute and Chronic Pain: Pathogenesis, Treatment Strategies and Care

A special issue of Neurology International (ISSN 2035-8377). This special issue belongs to the section "Pain Research".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 162

Special Issue Editors


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Guest Editor
1. Anesthesia and Intensive Care, “Vito Fazzi” Hospital, Lecce, Italy
2. Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
Interests: anesthesia; critical care; acute and chronic pain

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Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
Interests: chronic pain; intensive care; anesthesia; anesthesiology; mechanical ventilation; cancer pain; neuropathic pain
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Special Issue Information

Dear Colleagues,

Pain is an unpleasant sensory and emotional experience associated with, or similar to, actual or potential tissue damage. For some, acute pain lasts less than 30 days, while for others, acute pain can refer to any pain that resolves before 3 to 6 months. The IASP classification of chronic pain for the International Classification of Diseases (ICD-11) is defined as pain that persists or recurs for more than 3 months. Pain is one of the world's most significant health crises. Pain, both acute and chronic, negatively impacts virtually every aspect of a patient's life. In many cases, pain is the primary or only clinical problem in some patients.

The aim of this Special Issue is to study the complex interaction of biological (genetic, biochemical, etc.) and psychological (mood, thoughts) factors underlying the development of pain.

Another goal is to explore pain management with pharmacological and non-pharmacological approaches (e.g., exercise, cognitive behavioral therapy), and invasive approaches (neuromodulation, etc.) where necessary, and long-term pain management programs for people with persistent/chronic pain.

Dr. Luca Gregorio Giaccari
Dr. Pasquale Sansone
Guest Editors

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Keywords

  • acute pain
  • chronic pain
  • pathogenesis
  • translational pain
  • pain treatment
  • cognitive behavioral therapy
  • neuromodulation

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Published Papers (2 papers)

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10 pages, 1177 KiB  
Article
Development of a Novel Method of Spinal Electrophysiological Assessment via Intrathecal Administration at Analgesic Doses
by Daisuke Uta, Takuya Yamane, Sosuke Yoneda, Erika Kasai and Toshiaki Kume
Neurol. Int. 2025, 17(5), 78; https://doi.org/10.3390/neurolint17050078 - 21 May 2025
Abstract
Background/Objectives: Chronic pain is a significant global health challenge and is associated with diverse conditions, such as diabetic neuropathic pain and spinal stenosis. Understanding the mechanisms of pain transmission is crucial, for both the peripheral and central pathways. However, there are limitations [...] Read more.
Background/Objectives: Chronic pain is a significant global health challenge and is associated with diverse conditions, such as diabetic neuropathic pain and spinal stenosis. Understanding the mechanisms of pain transmission is crucial, for both the peripheral and central pathways. However, there are limitations in spinal electrophysiological techniques in terms of the injection method. Traditional methods such as spinal injections may differ in the distributions and concentrations of drugs compared with intrathecal administration during the behavior test. So, we developed a new intrathecal administration method for electrophysiological recordings. Methods: Sprague–Dawley rats were injected with lidocaine intrathecally, and the analgesic effect was evaluated by the von Frey test. In vivo extracellular single-unit recordings of the superficial dorsal horn neurons were performed following a newly developed technique. Lidocaine was intrathecally injected into the arachnoid membrane after laminectomy. After that, the neural responses in the superficial dorsal horn were measured. Results: Newly developed intrathecally administered dye reached the spinal cord and the cauda equina. Intrathecally administrated lidocaine increased the paw withdrawal threshold and suppressed spinal neuronal firing. This suppression correlated with increases in paw withdrawal thresholds. Conclusions: This innovative method provides insights into the central effects of analgesics, which will help the development of therapies for chronic pain. Full article
(This article belongs to the Special Issue Acute and Chronic Pain: Pathogenesis, Treatment Strategies and Care)
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26 pages, 1961 KiB  
Systematic Review
Medications for Managing Central Neuropathic Pain as a Result of Underlying Conditions—A Systematic Review
by Bjarke Kaae Houlind and Henrik Boye Jensen
Neurol. Int. 2025, 17(5), 77; https://doi.org/10.3390/neurolint17050077 - 20 May 2025
Abstract
Background: This systematic review assessed the current literature regarding the analgesic treatment of central neuropathic pain (CNP) in central nervous system (CNS) conditions, such as spinal cord injuries, multiple sclerosis, post-stroke disorders, and Parkinson’s disease. The aim of this systematic review was to [...] Read more.
Background: This systematic review assessed the current literature regarding the analgesic treatment of central neuropathic pain (CNP) in central nervous system (CNS) conditions, such as spinal cord injuries, multiple sclerosis, post-stroke disorders, and Parkinson’s disease. The aim of this systematic review was to compare the current algorithmic treatment of CNP, which generally does not discriminate among underlying conditions, with RCTs investigating algorithm-recommended and non-algorithm-recommended drugs for differing underlying conditions. Methods: The PubMed and EMBASE databases were used to identify relevant randomized control trials (RCTs). MeSH terms and EmTree terms were searched as well as free text words in the title/abstract of the studies. A risk of bias tool was used to assess all included studies. Results: A total of 903 RCTs were identified from the initial search. Thirty-eight RCTs published between January 2002 and November 2024 fulfilled all the inclusion criteria and none of the exclusion criteria. The review investigated progressive and stable neurological diseases and conditions with associated CNP. Conclusions: From the majority of the included studies, the current recommended treatment algorithm seems to be effective and safe; however, the underlying condition seems to influence how the patient responds to tier-appropriate medication. Full article
(This article belongs to the Special Issue Acute and Chronic Pain: Pathogenesis, Treatment Strategies and Care)
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