Mapping the Brain: Neural Correlates of Cognition and Mental Illness

A special issue of Neurology International (ISSN 2035-8377).

Deadline for manuscript submissions: 31 May 2026 | Viewed by 472

Special Issue Editors


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Guest Editor
Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy
Interests: psychosis; cognition; functioning; rehabilitation; autism
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy
Interests: imaging; diffusion tensor imaging; functional neuroimaging; neuroimaging; magnetic resonance; computed tomography; brain imaging; machine learning; fMRI; eye tracking
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human brain operates through complex, distributed networks that support a wide range of cognitive functions, including memory, attention, executive control, and emotional regulation. Recent advances in neuroimaging, electrophysiology, and computational modeling have enabled increasingly precise mapping of these neural systems, revealing how specific brain regions and their interactions give rise to cognition. This research has also illuminated how disruptions in these networks contribute to the pathophysiology of mental illnesses.

Functional and structural connectivity analyses, including graph-theoretical and multivariate pattern approaches, have identified key hubs—such as the prefrontal cortex, hippocampus, thalamus, and amygdala—whose altered dynamics are consistently associated with cognitive deficits and clinical symptoms. Moreover, longitudinal and multimodal studies suggest that aberrant neurodevelopmental trajectories and maladaptive plasticity underlie many psychiatric conditions. By integrating data across scales, this field is moving toward a systems-level understanding of brain function and dysfunction. Such insights are critical for developing mechanistically informed biomarkers and targeted interventions, ultimately bridging the gap between neuroscience and clinical psychiatry.

The main aim of this research topic is to delineate the neural circuits underlying core cognitive domains and elucidate how their dysregulation manifests in psychiatric and neurodevelopmental disorders.

Dr. Giacomo Deste
Dr. Daniele Corbo
Guest Editors

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Keywords

  • cognition
  • neural circuits
  • neurodevelopmental disorders
  • mental illness

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Published Papers (1 paper)

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12 pages, 920 KB  
Systematic Review
Nutritional Influences on the Brain in ADHD: Evidence from Neuroimaging Studies
by Daniele Corbo, Roberto Gasparotti, Francesca Bozzetti, Stefano Renzetti, Laura Clara Grandi, Antonio Vita and Giacomo Deste
Neurol. Int. 2026, 18(6), 107; https://doi.org/10.3390/neurolint18060107 - 29 May 2026
Abstract
Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) is increasingly recognized as a neurodevelopmental condition shaped by early-life biological and environmental factors. Emerging evidence highlights the role of nutrition in modulating key brain processes involved in ADHD, from gestational development through childhood. This review aims to examine [...] Read more.
Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) is increasingly recognized as a neurodevelopmental condition shaped by early-life biological and environmental factors. Emerging evidence highlights the role of nutrition in modulating key brain processes involved in ADHD, from gestational development through childhood. This review aims to examine how dietary interventions influence neuroimaging outcomes in individuals with ADHD, assessing whether nutritional approaches can modulate brain structure, function, or connectivity. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted to identify studies examining the effects of dietary interventions on neuroimaging outcomes in individuals with ADHD. Study quality was assessed using Cochrane RoB 2.0, ROBINS-I, the Newcastle–Ottawa Scale, and the JBI Critical Appraisal Checklist, according to study design. Results: A total of 1059 records were identified, and 4 studies met the final inclusion criteria. The included studies suggest that prenatal vitamin D exposure, omega-3 fatty acids, and micronutrients such as zinc may be associated with structural, functional, and neurometabolic brain characteristics relevant to ADHD. Reported findings included associations with brain volume, glutamatergic regulation, white matter organization, resting-state network integrity, and inattentive symptom. Conclusions: Current evidence supports the hypothesis that nutrition may influence neurodevelopmental processes involved in ADHD, including brain maturation and neural network organization. Although findings remain heterogeneous and limited in number, nutrition appears to represent a biologically plausible and potentially modifiable factor within the developmental framework of ADHD. Further longitudinal and multimodal neuroimaging studies are needed to clarify the mechanisms linking nutrition, brain development, and ADHD. Full article
(This article belongs to the Special Issue Mapping the Brain: Neural Correlates of Cognition and Mental Illness)
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