Topical Collection "Secreted Non-coding RNAs as Signaling Molecules Driving Cell-to-Cell Communication in Cancer"

Editor

Dr. Giulia Fontemaggi
E-Mail Website
Collection Editor
Regina Elena National Cancer Institute (IRCCS), Rome, Italy
Interests: microRNAs; lncRNAs; circRNA; tumor angiogenesis; tumor-associated macrophages; cancer biology; p53

Topical Collection Information

Dear Colleagues,

It is becoming increasingly clear that cancer cells actively communicate with a variety of cell types through the release of soluble mediators. This is crucial to the acquisition of diverse cancer-associated features, such as the ability to inhibit the immune recognition of malignant cells, the remodeling of the extracellular matrix (ECM), the establishment of an inflammatory state, the alteration of vascular permeability, and the preparation of the metastatic niche.

For decades, our studies have been focused on protein mediators, such as cytokines and chemokines, which strongly contribute to immune escape but also to neoangiogenesis in cancer.

More recently, cancer cells have been shown to have the ability to release non-coding RNAs (ncRNAs), such as microRNAs, long non-coding RNAs, and circular RNAs. ncRNAs are secreted in vesicles or associated with cargo proteins and might be involved in autocrine as well as in paracrine signaling networks, finally leading to the alteration of target cells' behavior in the protumorigenic sense. The targeting of ncRNAs, which mediate the cross-talk between cancer cells and other cells in the tumor microenvironement, is emerging as a promising approach to enhancing traditional anticancer treatments.

The purpose of this Topical Collection is to present a collection of articles (both original research articles and reviews) from experts in non-coding RNA research that highlight the important function of ncRNAs in cell-to-cell communication.

Dr. Giulia Fontemaggi
Collection Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microRNA, circRNA, and lncRNA in the tumor microenvironement
  • immune escape
  • liquid biopsy
  • extracellular matrix remodeling
  • chemoresistance
  • radioresistance

Published Papers (3 papers)

2022

Review
Circular RNAs Activity in the Leukemic Bone Marrow Microenvironment
Non-Coding RNA 2022, 8(4), 50; https://doi.org/10.3390/ncrna8040050 - 01 Jul 2022
Viewed by 469
Abstract
Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out [...] Read more.
Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML. Full article
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Review
Non-Coding RNAs in the Crosstalk between Breast Cancer Cells and Tumor-Associated Macrophages
Non-Coding RNA 2022, 8(1), 16; https://doi.org/10.3390/ncrna8010016 - 06 Feb 2022
Cited by 2 | Viewed by 1302
Abstract
Non-coding RNAs (ncRNAs) play a pivotal role in regulating the tumor microenvironment (TME) by controlling gene expression at multiple levels. In tumors, ncRNAs can mediate the crosstalk between cancer cells and other cells in the TME, such as immune cells, stromal cells, and [...] Read more.
Non-coding RNAs (ncRNAs) play a pivotal role in regulating the tumor microenvironment (TME) by controlling gene expression at multiple levels. In tumors, ncRNAs can mediate the crosstalk between cancer cells and other cells in the TME, such as immune cells, stromal cells, and endothelial cells, influencing tumor development and progression. Tumor-associated macrophages (TAMs) are among the most abundant inflammatory cells infiltrating solid cancers that promote tumorigenesis, and their infiltration correlates with a poor prognosis in many tumors. Cancer cells produce different ncRNAs that orchestrate TAM recruitment and polarization toward a tumor-promoting phenotype. Tumor-reprogrammed macrophages shape the TME by promoting angiogenesis and tissue remodeling, and suppressing the anti-tumor activity of adaptive immune cells. TAMs can also produce ncRNA molecules that boost cancer cell proliferation and direct their phenotype and metabolic changes facilitating cancer progression and metastasis. This review will focus on the crosstalk between cancer cells and TAMs mediated by microRNAs and long non-coding RNAs during breast cancer (BC) initiation and progression. Full article
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Review
Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer
Non-Coding RNA 2022, 8(1), 5; https://doi.org/10.3390/ncrna8010005 - 11 Jan 2022
Cited by 3 | Viewed by 1355
Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery. TNBC is devoid of estrogen, progesterone and HER2 receptors. Although precision medicine has come [...] Read more.
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery. TNBC is devoid of estrogen, progesterone and HER2 receptors. Although precision medicine has come a long way to ameliorate breast cancer disease management, targeted therapies for the treatment of TNBC patients are still limited. Mounting evidence has shown that non-coding RNAs (ncRNAs) drive many oncogenic processes at the basis of increased proliferation, invasion and angiogenesis in TNBC, strongly contributing to tumor progression and resistance to treatments. Many of these ncRNAs are secreted in the tumor microenvironment (TME) and impinge on the activity of the diverse immune and stromal cell types infiltrating the TME. Importantly, secreted ncRNAs may be detected as circulating molecules in serum/plasma from cancer patients and are emerging a promising diagnostic/therapeutic tools in TNBC. This review aims to discuss novel insights about the role of secreted circulating ncRNAs in the intercellular communication in the tumor microenvironment and their potential clinical use as diagnostic and prognostic non-invasive biomarkers in TNBC. Full article
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