Topical Collection "Secreted Non-coding RNAs as Signaling Molecules Driving Cell-to-Cell Communication in Cancer"
A topical collection in Non-Coding RNA (ISSN 2311-553X).
It is becoming increasingly clear that cancer cells actively communicate with a variety of cell types through the release of soluble mediators. This is crucial to the acquisition of diverse cancer-associated features, such as the ability to inhibit the immune recognition of malignant cells, the remodeling of the extracellular matrix (ECM), the establishment of an inflammatory state, the alteration of vascular permeability, and the preparation of the metastatic niche.
For decades, our studies have been focused on protein mediators, such as cytokines and chemokines, which strongly contribute to immune escape but also to neoangiogenesis in cancer.
More recently, cancer cells have been shown to have the ability to release non-coding RNAs (ncRNAs), such as microRNAs, long non-coding RNAs, and circular RNAs. ncRNAs are secreted in vesicles or associated with cargo proteins and might be involved in autocrine as well as in paracrine signaling networks, finally leading to the alteration of target cells' behavior in the protumorigenic sense. The targeting of ncRNAs, which mediate the cross-talk between cancer cells and other cells in the tumor microenvironement, is emerging as a promising approach to enhancing traditional anticancer treatments.
The purpose of this Topical Collection is to present a collection of articles (both original research articles and reviews) from experts in non-coding RNA research that highlight the important function of ncRNAs in cell-to-cell communication.Dr. Giulia Fontemaggi
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- microRNA, circRNA, and lncRNA in the tumor microenvironement
- immune escape
- liquid biopsy
- extracellular matrix remodeling