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Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer

1
Department of Health Sciences, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, Italy
2
Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: George A Calin
Non-Coding RNA 2022, 8(1), 5; https://doi.org/10.3390/ncrna8010005
Received: 15 December 2021 / Revised: 5 January 2022 / Accepted: 7 January 2022 / Published: 11 January 2022
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery. TNBC is devoid of estrogen, progesterone and HER2 receptors. Although precision medicine has come a long way to ameliorate breast cancer disease management, targeted therapies for the treatment of TNBC patients are still limited. Mounting evidence has shown that non-coding RNAs (ncRNAs) drive many oncogenic processes at the basis of increased proliferation, invasion and angiogenesis in TNBC, strongly contributing to tumor progression and resistance to treatments. Many of these ncRNAs are secreted in the tumor microenvironment (TME) and impinge on the activity of the diverse immune and stromal cell types infiltrating the TME. Importantly, secreted ncRNAs may be detected as circulating molecules in serum/plasma from cancer patients and are emerging a promising diagnostic/therapeutic tools in TNBC. This review aims to discuss novel insights about the role of secreted circulating ncRNAs in the intercellular communication in the tumor microenvironment and their potential clinical use as diagnostic and prognostic non-invasive biomarkers in TNBC. View Full-Text
Keywords: breast cancer; TNBC; non-coding RNA; ncRNA; exosomes; tumor microenvironment; liquid biopsy breast cancer; TNBC; non-coding RNA; ncRNA; exosomes; tumor microenvironment; liquid biopsy
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MDPI and ACS Style

Di Agostino, S.; Vahabi, M.; Turco, C.; Fontemaggi, G. Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer. Non-Coding RNA 2022, 8, 5. https://doi.org/10.3390/ncrna8010005

AMA Style

Di Agostino S, Vahabi M, Turco C, Fontemaggi G. Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer. Non-Coding RNA. 2022; 8(1):5. https://doi.org/10.3390/ncrna8010005

Chicago/Turabian Style

Di Agostino, Silvia, Mahrou Vahabi, Chiara Turco, and Giulia Fontemaggi. 2022. "Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer" Non-Coding RNA 8, no. 1: 5. https://doi.org/10.3390/ncrna8010005

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