Non-coding RNAs Involved in Cancer Chemoresistance
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 16295
2. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M1 7DN, UK
Interests: microRNA; miRNA; long noncoding RNA; lncRNA; noncoding RNA; ncRNA; cancer; tumour; chemoresistance; drug resistance
In the past two decades, following the discovery of the RNA interference pathway by Fire and Mello, the biological and clinical roles of noncoding RNA families of the ‘dark matter’ of the genome have evolved rapidly. Presently, these families include microRNAs and long noncoding RNA families that are already acknowledged to have widespread implications for all physiological processes within the mammalian cell through their highly effective gene regulatory roles. Consequently, noncoding RNA family elements can—when dysregulated—allow for the pathogenesis and progression of a myriad of medical conditions, including cancer. Furthermore, on focusing on the noncoding RNA influences in cancer, specific tumour characteristics can be exacerbated or inhibited through noncoding RNA direction. This Special Issue aims to delve deeper and consolidate all recent global research efforts (research articles/reviews) for specific noncoding RNA biomarker discovery and validation, including mechanistic implications of noncoding RNAs in the development (and regulation) of the drug resistant tumour phenotype, for possible theranostic exploitation in the near future.
Dr. Duncan Ayers
Dr. Ali Rihani
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- Long noncoding RNA
- noncoding RNA
- Drug resistance