Advanced Nanomedicine Methods for Drug Delivery and Tumor Microenvironment Modulation
A special issue of Methods and Protocols (ISSN 2409-9279). This special issue belongs to the section "Biomedical Sciences and Physiology".
Deadline for manuscript submissions: 10 October 2026 | Viewed by 160
Special Issue Editor
Interests: nanomedicine-based drug delivery and cancer immunotherapy; tumor microenvironment modulation and nano-enabled radio/chemo/immunotherapy
Special Issue Information
Dear Colleagues,
Nanotechnology-based drug delivery systems have emerged as powerful tools for improving therapeutic efficacy, safety, and precision across a wide range of biomedical applications. In particular, advances in nanomedicine have enabled sophisticated regulation of drug pharmacokinetics, biodistribution, cellular uptake, and interactions with the tumor microenvironment (TME). However, the successful translation of nanomedicine critically depends on robust, reproducible, and standardized experimental methods and protocols.
This Special Issue aims to collect high-quality methodological studies, experimental protocols, and technical advances related to nanomedicine-enabled drug delivery. A special emphasis is placed on nano-enabled strategies for modulating the tumor microenvironment, enhancing anticancer immunity, and improving therapeutic outcomes. By focusing on experimental design, fabrication strategies, characterization techniques, and biological evaluation methods, this Special Issue seeks to provide practical guidance and methodological insights for researchers in the field.
Topics of interest include, but are not limited to:
Design, synthesis, and characterization methods of nanomedicine-based drug delivery systems;
Experimental protocols for nano–bio interactions and cellular uptake mechanisms;
Nanoplatform fabrication strategies for controlled drug release and targeted delivery;
Methods for evaluating nanomedicine pharmacokinetics, biodistribution, and biosafety;
Nano-enabled modulation of the tumor microenvironment (e.g., hypoxia, metabolism, immune landscape);
Experimental approaches for nanomedicine-assisted cancer immunotherapy;
Protocols for in vitro and in vivo evaluation of nanodrug efficacy and immunological responses;
Reproducibility, standardization, and translational considerations in nanomedicine research.
This Special Issue welcomes original research articles, technical notes, methodological studies, and comprehensive protocol papers that advance the experimental toolkit and translational potential of nanomedicine-based drug delivery.
Dr. Zhusheng Huang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Methods and Protocols is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nanomedicine
- drug delivery systems
- tumor microenvironment
- cancer immunotherapy
- nano-enabled combination therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
