Pathogenesis and Antimicrobial Resistance of Enterobacter Infection

Dear Colleagues,

Enterobacter species is a facultative Gram-negative fermenter belonging to the Enterobacterales family and found ubiquitously in natural environments. Despite being a commensal member of the human and animals gastrointestinal tract (GIT) and respiratory tract, Enterobacter is considered an opportunistic pathogen. They are also frequently encountered in nosocomial settings, causing septicemia, respiratory, and wound infections. Carbapenems are the main drugs for the treatment of multidrug-resistant Enterobacter infections, but the rise of carbapenem resistance in Enterobacter species, primarily caused by the acquisition of carbapenemase-encoding genes, has significantly compromised the choice of clinical antimicrobial treatment. With an alarming crisis of carbapenem-resistant enterobacterales (CREs) worldwide, Enterobacter species contribute to rising CRE cases following E. coli and Klebsiella pnuemoniae. While some species display plasmid-mediated acquired resistance, most Enterobacter resistance is caused by the chromosomal AmpC beta-lactamase activity. This Special Issue describes the classification of clinically significant Enterobacter species and the pathogenic mechanisms contributing to its virulence and antimicrobial resistance. 

Prof. Dr. Yiwei Tang
Guest Editor

Dr. Phyu M. Thwe
Guest Editor Assistant

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• Enterobacter species
• E. coli
• Klebsiella pnuemoniae
• carbapenem-resistant enterobacterales
• pathogenesis
• antibiotic resistance