APP-Aβ Metabolism in Rare Cerebral Small Vessel Vasculitides
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 1069
Special Issue Editor
Interests: genetics; Alzheimer’s disease; neurodegenerative diseases; dementia; vascular
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
An imbalance between amyloid precursor protein (APP) production and degradation is the leading cause of familial and sporadic Alzheimer’s disease (AD), respectively. Importantly, cerebral small-vessel disease (cSVD) represents a critical factor that significantly influences AD onset and progression, and frequently co-exists with AD. A growing body of literature has described APP-Aβ metabolism in the classical sporadic and monogenic forms of cSVD. However, the association of APP-Aβ catabolism with rare inflammatory and immunologically mediated cSVD has not been deeply investigated. Therefore, the aim of this Special Issue is to describe clinical-pathological and laboratory features associated with APP-Aβ dysmetabolism in rare cerebral small-vessel Vasculitides, with a particular focus on cerebral amyloid angiopathy (CAA)-related inflammation (CAA-RI), amyloid-β-related angiitis (ABRA), eosinophilic granulomatosis with polyangiitis (EGPA), and rheumatoid vasculitis.
Dr. Celeste Sassi
Guest Editor
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Keywords
- APP-Aβ metabolism
- Alzheimer’s disease (AD)
- cerebral small-vessel disease (cSVD)
- amyloid angiopathy (CAA)-related inflammation (CAA-RI)
- amyloid-β-related angiitis (ABRA)
- eosinophilic granulomatosis with polyangiitis (EGPA)
- rheumatoid vasculitis
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