mTOR Regulation on Membrane Trafficking

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4017

Special Issue Editor


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Guest Editor
Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Interests: placenta; membrane trafficking; mTOR; nutrient transporters; SNAT; LAT; GLUT; fetal programming; islets

Special Issue Information

Dear Colleagues,

Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates a wide array of cellular functions, including the control of cytoskeleton dynamics and membrane trafficking. Membrane trafficking is one of the primary functions of the cell, providing a crucial communication link between the cell and its environment and ensuring the transport of lipids and proteins in a timely manner. The interconnection of membrane trafficking with intra- and extracellular stimuli and stress represents a remarkable and dynamic mechanism that allows cells to respond to such stimuli. For this Special Issue entitled “mTOR regulation on Membrane Trafficking”, we are seeking novel research or review articles highlighting the variety of machinery and regulatory mechanisms used in membrane trafficking and the importance of how mTOR regulates membrane traffic, how mTOR-mediated cytoskeleton trafficking is interlinked with other cellular events and processes, and how mTOR-mediated dysfunctional trafficking machinery has implications in health and disease.

Dr. Fredrick J. Rosario
Guest Editor

Manuscript Submission Information

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Keywords

  • mTOR
  • nutrient sensor
  • cytoskeleton
  • membrane trafficking
  • nutrient transport

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Published Papers (1 paper)

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Review

18 pages, 1419 KiB  
Review
The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy
by Bashar A. Alhasan, Sergei A. Gordeev, Aleksandra R. Knyazeva, Kseniia V. Aleksandrova, Boris A. Margulis, Irina V. Guzhova and Irina I. Suvorova
Membranes 2021, 11(11), 858; https://doi.org/10.3390/membranes11110858 - 7 Nov 2021
Cited by 6 | Viewed by 3568
Abstract
Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is increasingly regarded to fuel tumor recurrence. The concept of cancer cell dormancy is often considered as an adaptive response of [...] Read more.
Currently, the success of targeted anticancer therapies largely depends on the correct understanding of the dormant state of cancer cells, since it is increasingly regarded to fuel tumor recurrence. The concept of cancer cell dormancy is often considered as an adaptive response of cancer cells to stress, and, therefore, is limited. It is possible that the cancer dormant state is not a privilege of cancer cells but the same reproductive survival strategy as diapause used by embryonic stem cells (ESCs). Recent advances reveal that high autophagy and mTOR pathway reduction are key mechanisms contributing to dormancy and diapause. ESCs, sharing their main features with cancer stem cells, have a delicate balance between the mTOR pathway and autophagy activity permissive for diapause induction. In this review, we discuss the functioning of the mTOR signaling and autophagy in ESCs in detail that allows us to deepen our understanding of the biology of cancer cell dormancy. Full article
(This article belongs to the Special Issue mTOR Regulation on Membrane Trafficking)
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