Future Directions of Marine Myxobacteria and Their Natural Products
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 286
Special Issue Editor
Interests: microorganisms; myxobacteria; microbial natural products; drug discovery; phylogeny; taxonomy; systematics; metagenomics; genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last two decades, the myxobacteria that tolerate sea salts have emerged as distinct groups in the order Myxococcales. Similar to their terrestrial counterpart, the halophilic myxobacteria synthesize diverse and exclusive secondary metabolites with interesting antimicrobial and cytotoxic biological activities. Most of the compounds isolated and structurally elucidated are from the genera Enhygromyxa and Haliangium; however, very little is known about secondary metabolites from the few other marine- and estuarine- derived taxa. Since metagenomic studies indicate that marine myxobacteria are more diverse than expected in salt-containing habitats and host organisms such as sponges and seagrasses, the discovery of new compounds in the future can be expected. Moreover, some studies have linked the possible myxobacterial associations with marine sponges to the parallel production of similar compounds as in the cases of apicularen A and salicylihalamide A, bengamide E-F, chondromide A-D and jasplakinolide, microsclerodermin D, and saframycin Mx1 and renieramycin A. Although the cultivation of these microorganisms is very challenging due to their slow growth rate and poorly understood physiology, marine myxobacteria may still be worth investigating to discover novel compounds.
This Special Issue aims to invite scientists, researchers and academics to publish their latest findings within the following scope for marine- and estuarine-derived myxobacteria: 1) isolation and discovery of novel taxa; 2) metagenomic diversity, phylogenetic and genomic studies; 3) biosynthesis and metabolomics; 4) isolation and structure elucidation of novel compounds; 5) mode-of-action and structure-activity-related (SAR) studies of novel compounds.
Dr. Ronald O. Garcia
Guest Editor
Manuscript Submission Information
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Keywords
- Myxobacteria
- Halophilic
- Secondary metabolites
- Bioactive compounds
- Structure-activity-related (SAR) studies
- Drugs from marine myxobacteria
- Metagenomics
- Biodiversity
- Phylogenetics
- Biosynthesis
- Metabolomics
- Genomics
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