Host–Fungal Interplay: Virulence, Immunity, Antifungal Resistance, and Therapeutic Strategies

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (10 November 2025) | Viewed by 304

Special Issue Editors


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Guest Editor
1. CIBICI-CONICET, Laboratory of Innate Immunity to Fungal Pathogens, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
2. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Interests: fungal infections; fungal pathogenesis; host immune response

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Guest Editor
HIV/Infectious Diseases Services at AltaMed, Los Angeles, CA 90022, USA
Interests: infectious diseases; fungal infections; novel therapeutics

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Guest Editor
Primera Cátedra de Clínica Infectológica. Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
Interests: fungal infections; antifungal resistance; therapeutic approaches

Special Issue Information

Dear Colleagues,

The incidence of fungal infections is rising, posing significant challenges for both clinicians and researchers. The complexity of these infections demands a deeper understanding of fungal pathogenesis, host immune responses, and treatment strategies. Over the years, advancements in key aspects of fungal research have led to tangible progress in disease management.

In this Special Issue, we invite you to explore and discuss novel and relevant aspects of these versatile pathogens, including their virulence mechanisms, host defense strategies, the alarming rise in antifungal resistance, and innovative therapeutic approaches. We cordially invite you to contribute to this collection by sharing your latest findings and insights. Your work will help drive forward our understanding of fungal infections and pave the way for improved clinical strategies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Fungal pathogenesis;
  • Host immune response;
  • Innate immunity;
  • Virulence factors;
  • Biofilms;
  • Antifungal resistance;
  • Therapeutic approaches;
  • Immunomodulation;
  • Novel therapeutics;
  • Emerging fungal pathogens.

Dr. Claudia Elena Sotomayor
Dr. Juan Pablo Caeiro
Dr. Fernando Oscar Riera
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal pathogenesis
  • host immune response
  • antifungal resistance
  • therapeutic approaches
  • emerging fungal pathogens

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Published Papers (1 paper)

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Review

22 pages, 421 KB  
Review
From the Ground to the Clinic: The Evolution and Adaptation of Fungi
by Dario Corrêa-Junior, Daniel Zamith-Miranda, Susana Frases and Joshua D. Nosanchuk
J. Fungi 2026, 12(1), 8; https://doi.org/10.3390/jof12010008 - 23 Dec 2025
Abstract
Fungi constitute a diverse kingdom of eukaryotic organisms with remarkable adaptability, ranging from saprophytic decomposers to lethal human pathogens. This review synthesizes current insights into fungal adaptations that underline pathogenesis, focusing on enzymatic strategies including hydrolytic enzymes, metabolic and physiological plasticity such as [...] Read more.
Fungi constitute a diverse kingdom of eukaryotic organisms with remarkable adaptability, ranging from saprophytic decomposers to lethal human pathogens. This review synthesizes current insights into fungal adaptations that underline pathogenesis, focusing on enzymatic strategies including hydrolytic enzymes, metabolic and physiological plasticity such as thermotolerance and nutrient flexibility, and evasion of host immunity via mechanisms like melanin production and biofilm formation. We detail fungal survival tactics including spore formation and genomic and epigenetic plasticity, which contribute to resilience and evolution under environmental and host-imposed stresses. The escalating emergence of antifungal resistance and the global impact of environmental changes underscore urgent clinical challenges. Advances in diagnostics, novel therapeutics incorporating AI-assisted drug discovery, and integrated One Health approaches are poised to combat this growing threat. This comprehensive overview aims to guide future research and inform clinical management of fungal infections in an era of dynamic microbial evolution and environmental upheaval. Full article
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