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Journal of Molecular Pathology, Volume 6, Issue 3

September 2025 - 11 articles

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Articles (11)

  • Review
  • Open Access
1,519 Views
39 Pages

Gastric Epithelial Cell Plasticity and Molecular Mechanisms of Metaplastic Transformations in the Stomach

  • Sergii Vernygorodskyi,
  • Anton B. Tonchev and
  • Kameliya Zhechkova Bratoeva

16 September 2025

This research delves into the complex relationship between progenitor cells and the differentiated cell types that make up the stomach. It highlights the need for further investigation into the mechanisms governing stomach development and how these m...

  • Review
  • Open Access
1,623 Views
20 Pages

The Current Landscape of Molecular Pathology for the Diagnosis and Treatment of Ependymoma

  • Alyssa Steller,
  • Ashley Childress,
  • Alayna Koch,
  • Emma Vallee and
  • Scott Raskin

4 September 2025

Ependymomas are a heterogeneous group of central nervous system tumors originating from ependymal cells, exhibiting significant variability in clinical behavior, prognosis, and treatment response based on anatomical location and molecular profile. Hi...

  • Article
  • Open Access
1,036 Views
9 Pages

Evaluation of a New Ethanol-Based Preservative Medium for Liquid-Based Cervical Cytology: A Performance Pilot Study for Molecular Applications

  • Floriana Conticelli,
  • Pasquale Pisapia,
  • Antonino Iaccarino,
  • Maria Salatiello,
  • Alessandro Venuta,
  • Gianluca Gragnano,
  • Luca Vallefuoco,
  • Rosanna Sorrentino,
  • Giuseppe Portella and
  • Nadia Casatta
  • + 4 authors

2 September 2025

Background: Since liquid-based cytology (LBC) has replaced the conventional Papanicolaou test in cervical cancer screening programs, pre-analytical procedures—particularly the choice of LBC collection media—have become crucial to ensure t...

  • Communication
  • Open Access
1,038 Views
8 Pages

2 September 2025

Background: Bone tissue decalcification is essential for histopathological evaluation, but conventional methods using inorganic acids degrade nucleic acids, limiting molecular testing. EDTA is known to better preserve DNA, but its suitability for nex...

  • Review
  • Open Access
1 Citations
2,809 Views
26 Pages

Cancer remains a leading global health challenge, with conventional diagnostic and treatment methods often lacking precision and adaptability. This review explores transformative advancements that are reshaping oncology by addressing these limitation...

  • Brief Report
  • Open Access
970 Views
9 Pages

ERBB2 Mutation Testing in NSCLC: A Pan-European Real-World Evaluation of the Oncomine Precision Assay

  • Ilaria Alborelli,
  • Melanie Demes,
  • Peter Wild,
  • Susana Hernandez,
  • Fernando Lopez-Rios,
  • Olivier Bordone,
  • Christophe Bontoux,
  • Paul Hofman,
  • Caterina De Luca and
  • Giancarlo Troncone
  • + 9 authors

Background/Objectives: The non-small-cell lung cancer (NSCLC) therapeutic landscape has undergone a profound transformation with the introduction of multiple personalized treatment options. Mutations in ERBB2 (HER2) have recently emerged as promising...

  • Review
  • Open Access
3,280 Views
14 Pages

Mechanism of Sepsis

  • Hideaki Yamamoto,
  • Muhammad Usman,
  • Aristides Koutrouvelis and
  • Satoshi Yamamoto

Sepsis is a complex and life-threatening syndrome arising from a dysregulated immune response to infection that can lead to severe organ dysfunction and increased mortality. This multifactorial condition is marked by intricate interactions between im...

  • Review
  • Open Access
1,225 Views
11 Pages

The Current Landscape of Molecular Pathology for the Diagnosis and Treatment of Pediatric High-Grade Glioma

  • Emma Vallee,
  • Alyssa Steller,
  • Ashley Childress,
  • Alayna Koch and
  • Scott Raskin

Pediatric high-grade glioma (pHGG) is a devastating group of childhood cancers associated with poor outcomes. Traditionally, diagnosis was based on histologic and immunohistochemical characteristics, including high mitotic activity, presence of necro...

  • Article
  • Open Access
5,720 Views
11 Pages

Background: Methylene blue (MB), a versatile redox agent, is emerging as a promising therapeutic in diseases associated with mitochondrial dysfunction. Its ability to optimize the electron transport chain increases ATP synthesis (30–40%) and re...

  • Article
  • Open Access
887 Views
12 Pages

Impact of hMLH1 −93G>A (rs1800734) and hMSH2 1032G>A (rs4987188) Polymorphisms on Colorectal Cancer Susceptibility

  • Bayram Bayramov,
  • Nigar Karimova,
  • Nigar Mehdiyeva,
  • Hagigat Valiyeva,
  • Rena Karimova,
  • Royal Shirinov,
  • Hazi Aslanov,
  • Zumrud Safarzade,
  • Orkhan Isayev and
  • Nuru Bayramov

Background: This study is the first to investigate the association between colorectal cancer (CRC) risk and the hMLH1 −93G>A and hMSH2 1032G>A polymorphisms of mismatch repair (MMR) genes in the Azerbaijani population. Methods: Peripheral...

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J. Mol. Pathol. - ISSN 2673-5261Creative Common CC BY license