Tissue Microarray from Cell Block Material (cbTMA)—An Additional Shot for Cytology in the Predictive Pathology Era: The PD-L1 Experience
Abstract
:1. Introduction
2. Materials and Methods
2.1. Samples
2.2. TMA Construction
2.3. PD-L1 Immunohistochemistry
3. Results
3.1. Samples
3.2. TMA
4. PD-L1 Immunohistochemistry
5. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Unique TMA Sample ID | Primary Tumor | Donor Core Height (mm) | PD-L1 IHC |
---|---|---|---|
1 | Urothelial carcinoma | 6.021 | - |
2 | Papillary thyroid carcinoma | 5.797 | - |
3 | Carcinoma, NOS | 5.963 | - |
4 | Carcinoma, gastrointestinal origin | 5.948 | - |
5 | Squamous cell carcinoma | 6.11 | +neoplastic cells |
6 | Carcinoma, NOS | 5.74 | - |
7 | Breast carcinoma | 6.133 | - |
8 | Squamous cell carcinoma | 5.529 | +immune cells |
9 | Squamous cell carcinoma | 6.013 | - |
10 | Squamous cell carcinoma | 4.792 | - |
11 | Ovarian serous carcinoma | 6.045 | - |
12 | Breast carcinoma | 5.887 | - |
13 | Squamous cell carcinoma | 6.014 | - |
14 | Squamous cell carcinoma | 5.768 | - |
15 | Breast carcinoma | 5.514 | - |
16 | Breast carcinoma | 5.796 | - |
17 | Medullary thyroid carcinoma | 5.883 | - |
18 | Squamous cell carcinoma | 5.615 | - |
19 | Colon carcinoma | 5.322 | - |
20 | Carcinoma, NOS | 5.63 | - |
21 | Pancreatic carcinoma | 5.508 | - |
22 | Colon carcinoma | 5.946 | - |
23 | Carcinoma, gastrointestinal origin | 4.904 | - |
24 | Breast carcinoma | 5.177 | - |
25 | Squamous cell carcinoma | 6.016 | +neoplastic and immune cells |
26 | Colon carcinoma | 5.705 | - |
27 | Colon carcinoma | 5.338 | - |
28 | Carcinoma, NOS | 5.312 | - |
29 | Papillary thyroid carcinoma | 5.062 | - |
30 | Ovarian serous carcinoma | 5.564 | - |
31 | Breast carcinoma | 5.617 | +immune cells |
32 | Pancreatic carcinoma | 5.857 | - |
33 | Breast carcinoma | 5.179 | - |
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Iaccarino, A.; Acanfora, G.; Pisapia, P.; Malapelle, U.; Bellevicine, C.; Troncone, G.; Vigliar, E. Tissue Microarray from Cell Block Material (cbTMA)—An Additional Shot for Cytology in the Predictive Pathology Era: The PD-L1 Experience. J. Mol. Pathol. 2022, 3, 15-23. https://doi.org/10.3390/jmp3010002
Iaccarino A, Acanfora G, Pisapia P, Malapelle U, Bellevicine C, Troncone G, Vigliar E. Tissue Microarray from Cell Block Material (cbTMA)—An Additional Shot for Cytology in the Predictive Pathology Era: The PD-L1 Experience. Journal of Molecular Pathology. 2022; 3(1):15-23. https://doi.org/10.3390/jmp3010002
Chicago/Turabian StyleIaccarino, Antonino, Gennaro Acanfora, Pasquale Pisapia, Umberto Malapelle, Claudio Bellevicine, Giancarlo Troncone, and Elena Vigliar. 2022. "Tissue Microarray from Cell Block Material (cbTMA)—An Additional Shot for Cytology in the Predictive Pathology Era: The PD-L1 Experience" Journal of Molecular Pathology 3, no. 1: 15-23. https://doi.org/10.3390/jmp3010002