Special Issue "Molecular and Functional Optical Imaging for Disease Diagnosis and Therapy Monitoring"

A special issue of Journal of Imaging (ISSN 2313-433X).

Deadline for manuscript submissions: closed (16 February 2018)

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. Ulas Sunar

Dept of Biomedical, Indust. & Human Factors Eng., Ohio Research Scholar for Medical Imaging, Wright State University, Dayton, OH 45431, USA
Website | E-Mail
Interests: diffuse optical imaging; biomedical optics; fluorescence imaging; photoacoustic imaging; imaging-guided intervention; optical imaging biomarkers; light therapy; photodynamic therapy; therapy response monitoring; optical blood flow and oxygenation
Guest Editor
Prof. Dr. Xavier Intes

Biomedical Engineering department, Rensselaer Polytechnic Institute, 110 8th street, JEC 7036, Troy, NY 12180, USA
Website | E-Mail
Interests: optical imaging; biophotonics; optical inverse problem; multimodal imaging; fluorescence imaging; functional imaging; time-resolved imaging; Monte Carlo; compressive sensing; lifetime sensing

Special Issue Information

Dear Colleagues,

Optical imaging has greatly impacted medicine by facilitating the early detection and staging of diseases, by guiding the development and selection of personalized treatment, and by offering efficient therapeutic modalities. Among the wide range of optical imaging approaches, diffuse optical imaging, which encompasses mesoscopic and macroscopic imaging techniques, is emerging as a powerful non-invasive modality for functional and molecular imaging of intact specimens. The success of diffuse optical imaging relies on the integration of dedicated instrumentation with refined data processing techniques to fulfil unmet clinical and preclinical needs.

The aims and scope of this Special Issue are to provide a novel strong and established source of information to introduce non-optical imaging experts to this field and its application; to review and share recent developments in novel functional and molecular imaging techniques; and to demonstrate the clinical potential of optical imaging. We invite investigators to contribute original research articles that will stimulate the continuing translational efforts to bring diffuse optical imaging from the bench to the bedside. We are particularly interested in articles describing new instrumental or computational/software approaches and/or applications in clinical and preclinical settings.

This Special Issue is primarily focused on the following topics However we encourage all submissions related to diffuse optical imaging:

  • Development and validation of new imaging instrumentation/approaches.
  • Development of new reconstruction algorithms and data processing techniques for diffuse optical imaging.
  • Functional, Molecular and structural diffuse optical imaging.
  • Devices and methods to guide therapeutic intervention.
  • Multimodal imaging integrating structural, molecular and functional information.
  • Multiphysics imaging including photo-acoustics, acousto-optics, etc.
  • 2D, 3D, 4D, tomographic and/or multi-spectral imaging.
  • Clinical and pre-clinical applications of the techniques (breast, brain, guided surgery, etc.).

Assoc. Prof. Dr. Ulas Sunar
Prof. Dr. Xavier Intes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Imaging is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Optical imaging
  • Biophotonics
  • Biomedical optics
  • Optical inverse problem
  • Multimodal imaging
  • Fluorescence imaging
  • Photoacoustic imaging
  • Functional imaging
  • Time-resolved imaging
  • Monte Carlo
  • Compressive sensing
  • Lifetime sensing
  • Imaging-guided intervention
  • Biomarkers
  • Light therapy
  • Photodynamic therapy
  • Therapy response monitoring
  • Optical blood flow and oxygenation

Published Papers (1 paper)

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Open AccessReview Cerebral Hemodynamic Influences in Task-Related Functional Magnetic Resonance Imaging and Near-Infrared Spectroscopy in Acute Sport-Related Concussion: A Review
J. Imaging 2018, 4(4), 59; https://doi.org/10.3390/jimaging4040059
Received: 28 February 2018 / Revised: 28 March 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
PDF Full-text (445 KB) | HTML Full-text | XML Full-text
One of the challenges of managing athletes with sport-related concussion (SRC) is guiding them to a safe return to play. A potential biomarker for use in the clinical assessment of recovery is the analysis of brain activation patterns during task-related functional Magnetic Resonance
[...] Read more.
One of the challenges of managing athletes with sport-related concussion (SRC) is guiding them to a safe return to play. A potential biomarker for use in the clinical assessment of recovery is the analysis of brain activation patterns during task-related functional Magnetic Resonance Imaging (fMRI). However, fMRI studies have provided conflicting results regarding what is pathological. An element that can contribute to this disagreement are hemodynamic impairments of the brain that follow a concussion. A functional neuroimaging technique based on the optical properties of brain tissue—called functional near-infrared spectroscopy (fNIRS)—can be used to evaluate SRC athletes, partially taking into consideration these brain hemodynamic impairments. However, so far, fNIRS has not been extensively used in concussion. In this critical review, there is a description of the main fMRI results involving the neocortex in acutely concussed patients, the influences of hemodynamic impairments on fMRI and fNIRS and the advantages and disadvantages of fNIRS to limit this influence. Full article

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