Special Issue "Genetics and Treatment of Dilated Cardiomyopathy"
A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).
Deadline for manuscript submissions: closed (30 June 2017).
Interests: cardiomyopathy; sarcomere; zebrafish; modifying screen; animal models; genome editing
JCDD launches a Special Issue on “Genetics and Treatment of Dilated Cardiomyopathy”. Idiopathic dilated cardiomyopathy (DCM) is a heritable, progressive disorder that ultimately leads to heart failure. The identification of many causative genes and key pathological pathways opens the door to new therapeutic strategies. However, the development of effective therapy is significantly hindered by the heterogeneous nature of DCM, manifesting as both locus heterogeneity, i.e., mutations in different genes result in DCM, and phenotypic variation, i.e., individuals with the same causative mutation could exhibit highly variable phenotypes. Therefore, strategies that enable the categorization of DCM into different types and development of individualized medicine tailored for different DCM types are needed. The advent of genomic tools and the integration of in vitro and in vivo models offer new research opportunities to identify the remaining causative genes, to pinpoint underlying mechanisms and to identify effective therapies.
Prof. Dr. Xiaolei Xu
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.
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- Dilated cardiomyopathy
- Genetic modifiers
- Mutagenesis screen
- Individualized medicine
- Drug repurposing
- Animal models