Left–Right Asymmetry and Cardiac Morphogenesis

Dear Colleagues,

Journal of Cardiovascular Development and Disease (JCDD) launches a Special Issue on left–right asymmetry in cardiac morphogenesis. The mature heart is a highly asymmetric structure, which originates from symmetrically organized paired heart fields at the primitive streak stage. Asymmetry within the heart is generated by different processes, which include determination of left–right atrial identity, looping and asymmetric remodeling. These processes are globally summarised under the term “cardiac laterality”. Correct heart development crucially depends on proper establishment of its laterality and not surprisingly severe congenital cardiac pathologies can be traced back to an impairment of this process. The establishment and regulation of cardiac laterality depends on proper establishment of the left–right axis during early embryogenesis and is a complex issue, which implies the fine interplay between molecular, cellular, and biophysical processes.

This thematic issue will cover the state-of-the-art knowledge on the mechanisms establishing cardiac laterality and left–right axis formation and will offer a perspective on its impact on congenital heart disease.

Dr. Marina Campione
Prof. Dr. Thomas Brand
Guest Editors

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