Targeted Therapeutic Delivery for Cardiac Regeneration and Myocardial Repair
A Special Issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425) belonging to the section "Cardiac Development and Regeneration".
Deadline for manuscript submissions: 31 May 2027 | Viewed by 75
Editors
Interests: heart; skeletal muscle; 3D bioprinting; electroconductive materials; cancer biology; kidney
Special Issues, Collections and Topics in MDPI journals
Interests: cardiac regeneration; congenital heart disease; myocardial and endothelial dysfunction; targeted therapeutic delivery; iPSC-derived cardiovascular models; multiomics and precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The limited regenerative capacity of the adult heart remains a major barrier to recovery after myocardial injury. Targeted delivery technologies offer a promising strategy to activate endogenous repair pathways while improving therapeutic retention, cell specificity and safety. This Special Issue will focus on delivery systems designed to promote cardiomyocyte proliferation, vascular regeneration, immune-mediated repair and functional myocardial recovery.
We welcome original research, reviews and perspectives on lipid nanoparticles, extracellular vesicles, biomimetic carriers, injectable hydrogels, cardiac-targeting peptides, viral vectors and stimuli-responsive platforms. Particular emphasis will be placed on the delivery of mRNA, siRNA, microRNAs, proteins, gene-editing systems, small molecules and regenerative biologics to cardiomyocytes, endothelial cells, fibroblasts, progenitor cells and reparative immune-cell populations.
Priority topics include transient reactivation of cardiomyocyte cell-cycle programs, mitochondrial rescue, angiogenesis, fibrosis reversal, macrophage reprogramming, extracellular-matrix remodeling and the modulation of cell-death pathways that limit regeneration. Studies using iPSC-derived cardiac models, organoids, engineered heart tissues, myocardial slices, spatial biology and in vivo imaging are especially encouraged. This collection aims to define design principles for precise regenerative delivery and accelerate the translation of targeted therapies capable of restoring myocardial structure and function.
Prof. Dr. Felix Engel
Guest Editor
Dr. Ankit Kushwaha
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- targeted cardiac delivery
- myocardial regeneration
- regenerative therapeutics
- lipid nanoparticles
- extracellular vesicles
- injectable hydrogels
- mRNA and gene therapy
- cardiomyocyte proliferation
- angiogenesis
- cardiac tissue engineering.
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