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Special Issue "Migraine: Symptoms, Causes, Diagnosis and Treatment"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: 31 March 2023 | Viewed by 890

Special Issue Editor

Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80100 Naples, Italy
Interests: migraine; pediatric neurology; pediatric psychiatry; behavioral problems; learning disorders; movement disorders; sleep; headache and intellectual disabilities

Special Issue Information

Dear Colleagues,

A migraine is a moderate or severe headache that usually manifests as a throbbing pain on one side of the head. It is a common disabling primary headache disorder that directly affects more than one billion people worldwide. According to the Global Burden of Disease Study, migraines constitute the second most prevalent neurological disorder worldwide and are responsible for more disabilities than all other neurological disorders combined.

The pathogenesis of a migraine is widely believed to involve the peripheral and central activation of the trigeminovascular system. Genetic factors might play a significant role in determining an individual’s susceptibility to migraine. However, much remains unknown about specific pathogenic processes. The functioning of individuals who experience migraines may be limited in their daily life during ictal phases. They are also more likely to have other somatic symptoms (e.g., abdominal pain), anxiety and mood disorders. In addition, it has been reported that chronic migraines in the developmental age often seem to be associated with psychiatric, neurological and cardiac comorbidities, learning impairments and sleep problems. Some drugs can treat or prevent migraines, and exercise has been studied as a migraine-preventive treatment, but currently, there is no cure for migraine headaches.

This Special Issue is dedicated to increasing our awareness and understanding of migraines, which will improve the lives of those living with them. We welcome studies that report the symptoms, causes, diagnoses and treatments of migraines.

Prof. Dr. Maria Esposito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • migraine
  • headache
  • neck stiffness
  • childhood migraine
  • migraine comorbidities
  • aura
  • cortical spreading depression
  • treatment

Published Papers (1 paper)

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Acupuncture Is Effective at Reducing the Risk of Stroke in Patients with Migraines: A Real-World, Large-Scale Cohort Study with 19-Years of Follow-Up
Int. J. Environ. Res. Public Health 2023, 20(3), 1690; https://doi.org/10.3390/ijerph20031690 - 17 Jan 2023
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Migraines are common headache disorders and risk factors for subsequent strokes. Acupuncture has been widely used in the treatment of migraines; however, few studies have examined whether its use reduces the risk of strokes in migraineurs. This study explored the long-term effects of [...] Read more.
Migraines are common headache disorders and risk factors for subsequent strokes. Acupuncture has been widely used in the treatment of migraines; however, few studies have examined whether its use reduces the risk of strokes in migraineurs. This study explored the long-term effects of acupuncture treatment on stroke risk in migraineurs using national real-world data. We collected new migraine patients from the Taiwan National Health Insurance Research Database (NHIRD) from 1 January 2000 to 31 December 2017. Using 1:1 propensity-score matching, we assigned patients to either an acupuncture or non-acupuncture cohort and followed up until the end of 2018. The incidence of stroke in the two cohorts was compared using the Cox proportional hazards regression analysis. Each cohort was composed of 1354 newly diagnosed migraineurs with similar baseline characteristics. Compared with the non-acupuncture cohort, the acupuncture cohort had a significantly reduced risk of stroke (adjusted hazard ratio, 0.4; 95% confidence interval, 0.35–0.46). The Kaplan–Meier model showed a significantly lower cumulative incidence of stroke in migraine patients who received acupuncture during the 19-year follow-up (log-rank test, p < 0.001). Acupuncture confers protective benefits on migraineurs by reducing the risk of stroke. Our results provide new insights for clinicians and public health experts. Full article
(This article belongs to the Special Issue Migraine: Symptoms, Causes, Diagnosis and Treatment)
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