Advances in Metal Exposure and Lung Diseases
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".
Deadline for manuscript submissions: closed (30 October 2022) | Viewed by 558
Special Issue Editors
Interests: toxicology of metals; occupational and environmental medicine; biomarkers of exposure and effects; biostatistics; clinical epidemiology; nanotoxicology
Interests: occupational medicine; pneumology; lung cancer; professional diseases; biomonitoring
Special Issue Information
Dear Colleagues,
The acute or chronic exposure to toxic metallic elements is a known risk factor for the development of pulmonary diseases both in occupationally and environmentally polluted environments. Metallic elements can accumulate in the airways both in soluble and non-soluble forms (ultra-fine or fine particles or metal containing engineered nanoparticles) and can interact with pulmonary tissues, inducing several toxic effects (i.e. oxidative stress, direct interaction with proteins and DNA, etc.) which leads to several pulmonary diseases, among which lung cancer. The traditional biomonitoring of metallic elements is based on the direct determination of them in biological matrices, like blood and urine, that reflect a systemic exposure. However, in recent years, new methodologies have been developed to detect the effective dose at the target organ level, by monitoring the metallic concentrations in new biological fluids, such as exhaled breath condensate and induced sputum. Furthermore, direct relationships between biomarkers of exposure and effects have been observed in exposed workers, showing molecular modifications of the airways also in the absence of clear disease signs.
This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the recent advances on the relationship between metal exposure and lung diseases. Research papers on metal single or multiple exposure and risk assessment, determination of new biomarkers of exposure and effects, mechanisms of metal pneumotoxicity, also in the nano form, are welcome to this issue. Furthermore, general and systematic reviews, epidemiological studies, case reports and conference papers about the same topics are also welcome.
Prof. Dr. Matteo Goldoni
Prof. Massimo Corradi
Dr. Sara Tagliaferri
Guest Editors
Manuscript Submission Information
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Keywords
- metal exposure
- lung diseases
- biomonitoring
- pneumotoxicology
- risk assessment
- exposed workers
- metal polluted environments
- lung target dose
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