Anti-cancer Activity for Cancer Prevention and Treatment

Dear Colleagues,

Cancer represents the second leading cause of death worldwide. Despite the advances in the treatment of several cancer types, current available therapies often fail, and patients develop drug resistance. In the last few decades, considerable efforts have been made to discover new therapeutical and prevention strategies. However, novel attempts are needed to deepen our understanding of molecular mechanisms underlying multifaceted cancers, identify new therapeutic targets and design innovative drugs for cancer management.

A significant number of natural compounds, both plant- and fungus-derived, are employed for cancer prevention and treatment. Moreover, several studies have reported that natural bioactive compounds could enhance chemotherapy’s efficacy and ameliorate some of the chemotherapeutic agent side-effects. With the increasing application of molecular biology in oncology research, there has been considerable interest in studying the anti-tumor effects of these natural compounds and identifying the possible underlying mechanisms. Although numerous in vitro and in vivo studies and even clinical trials confirm the direct inhibitory effects of natural compounds on cancer cells, the exact molecular mechanism underlying these effects is still poorly understood.

This Special Issue aims to cover recent advances in the detection of new therapeutic targets and on molecular mechanisms underlying the development and progression of cancers.

We invite eminent researchers worldwide to submit both original research and review articles that:

• Summarize our knowledge of molecular mechanisms displaying a pivotal role in cancer and possibly representing an effective target for therapy;
• Provide new insights into the mechanism of action and the signaling pathways induced by natural bioactives, phytochemicals and novel compounds, with anti-cancer properties in cancer cells as well as host immune cells useful in cancer prevention and therapy;
• Assess the therapeutic efficacy of molecular-targeted drugs;
• Disclose novel therapeutic approaches;
• Focus on the clinical application of new compounds displaying anti-cancer activities.

Dr. Erika Zazzo
Dr. Monica Rienzo
Dr. Małgorzata Pawlikowska
Dr. Felice Crocetto
Dr. Octavian Sabin Tataru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.