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Human Exposure to Genotoxic Environmental Contaminants

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1403

Special Issue Editors


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Guest Editor
Laboratorio de Genotoxicología Ambiental, Facultad de Ciencias, Universidad Autónoma de Baja California, Ensenada 22860, Mexico
Interests: intersection of biology, environmental science, and advanced technologies; environmental genotoxicity; micronuclei assays in various biological models; nanotechnology and biomedical applications; selective toxicity of silver nanoparticles against cancerous and healthy cell lines

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Guest Editor
Medicina Interna II, Facultad de Medicina, Universidad Autonoma de Guadalajara, Zapopan 45129, Mexico
Interests: impact of environmental pollutants and advanced materials on biological systems; genotoxic effects of industrial chemicals, pharmaceuticals, and nanomaterials on human health and the environment

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Human Exposure to Genotoxic Environmental Contaminants", aims to address the pressing concerns surrounding the impact of various environmental pollutants on human health. As industrial activities, agricultural practices and urbanization continue to introduce a wide array of contaminants into the environment, meaning that there is a critical need to understand their genotoxic effects. This Special Issue aims to cover various pollutants, including industrial chemicals, agricultural pesticides, pharmaceuticals, and emerging contaminants such as nanomaterials. We welcome the submission of original research, reviews, and case studies that employ innovative methodologies to assess these contaminants' genotoxicity and overall health impacts. Studies utilizing micronuclei assays, biomonitoring, in vitro and in vivo models, and epidemiological approaches are particularly encouraged to be submitted. Additionally, contributions that focus on risk assessment and nanogenotoxicology are highly encouraged. By bringing together cutting-edge research, this Special Issue aims to enhance our understanding of the risks posed by environmental contaminants and to inform regulatory policies and public health interventions.

Dr. María Evarista Arellano
Dr. Olivia Torres Bugarin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genotoxicity
  • environmental contaminants
  • industrial pollutants
  • agricultural pesticides
  • pharmaceuticals
  • nanomaterials
  • micronuclei assays
  • human health risk
  • nanogenotoxicology
  • regulatory policies

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Published Papers (1 paper)

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Research

13 pages, 1970 KiB  
Article
Protective Effect of Silver Nanoparticles Against Cytosine Arabinoside Genotoxicity: An In Vivo Micronucleus Assay
by Idalia Yazmin Castañeda-Yslas, Olivia Torres-Bugarín, María Evarista Arellano-García, Balam Ruiz-Ruiz, Juan Carlos García-Ramos, Yanis Toledano-Magaña, Alexey Pestryakov and Nina Bogdanchikova
Int. J. Environ. Res. Public Health 2024, 21(12), 1689; https://doi.org/10.3390/ijerph21121689 - 18 Dec 2024
Cited by 1 | Viewed by 894
Abstract
Cancer treatments have harmful side effects, including genotoxic ones. Our previous research discovered that a specific silver nanoparticle (AgNPs) formulation could reduce the genotoxic effects of an alkylating agent, cyclophosphamide. This study aims to evaluate if this protective effect is observed against an [...] Read more.
Cancer treatments have harmful side effects, including genotoxic ones. Our previous research discovered that a specific silver nanoparticle (AgNPs) formulation could reduce the genotoxic effects of an alkylating agent, cyclophosphamide. This study aims to evaluate if this protective effect is observed against an antimetabolite anticancer agent, cytosine arabinoside (Ara-C). An erythrocyte micronucleus assay was conducted on BALB/c mice. A most significant effect was observed after the application scheme, including three doses of Ara-C and three subsequent doses of AgNPs, resulting in a 3.7 and 2.0-fold decrease in the frequency of micronucleated reticulocytes and accumulated erythrocytes, respectively. Current and previous studies reveal that AgNPs could be used as a genoprotector against the genotoxic damage produced by the currently used antineoplastic antimetabolites and alkylating agents. It was revealed that AgNPs could be considered a new class of promising synthetic antineoplastic genoprotectants along with the known class of derivatives from natural sources. Full article
(This article belongs to the Special Issue Human Exposure to Genotoxic Environmental Contaminants)
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